发表状态 | 已发表Published |
题名 | Clinical characteristics and prognosis of pediatric Listeria monocytogenes meningitis based on 10-year data from a large children's hospital in China |
作者 | |
发表日期 | 2024-03-01 |
发表期刊 | Microbiology Spectrum
![]() |
ISSN/eISSN | 2165-0497 |
卷号 | 12期号:3 |
摘要 | This study aims to summarize the clinical characteristics and prognosis of Listeria monocytogenes (LM) meningitis in children in Chongqing, China. A retrospective analysis of the clinical data and follow-up results of 20 LM meningitis patients admitted to the Children’s Hospital of Chongqing Medical University (CHCMU) from January 2012 to December 2022 was performed. The LM meningitis incidence rate was between 0 and 14.3 per 100,000 persons. The median age at onset was 8.98 months. There were five neonate cases, which all had perinatal abnormalities. Seven non-neonatal cases (7/15, 46.7%) had a documented history of contaminated food intake. One case had primary immunodeficiency. The most common symptoms were fever (20/20), altered consciousness (19/20), and vomiting (15/20). Seven cases had seizures, eight cases had cranial nerve involvement, eight cases had positive Babinski sign, and 10 cases had positive meningeal signs. The most common complications were hyponatremia (6/20), hypokalemia (6/20), respiratory failure (5/20), subdural effusion (3/20), and hydrocephalus (2/20). Treatment primarily involved monotherapy or combination therapy with meropenem (15/20) and ampicillin (10/20). Fifteen cases were treated with monotherapy or combination therapy using vancomycin. Twelve cases were successfully followed up from 10 months to 9 years and 6 months, and all had favorable long-term outcomes. LM meningitis incidence in children is low and with nonspecific clinical manifestations. Strengthening food hygiene and safety education, and avoiding infections during pregnancy are important to prevent LM infection in neonates and high-risk individuals. Meropenem and ampicillin are the preferred treatments. Early diagnosis and treatment can improve prognosis. |
关键词 | children clinical characteristics KEYWORDS Listeria monocytogenes meningitis treatment |
DOI | 10.1128/spectrum.03244-23 |
URL | 查看来源 |
收录类别 | SCIE |
语种 | 英语English |
WOS研究方向 | Microbiology |
WOS类目 | Microbiology |
WOS记录号 | WOS:001151739800001 |
Scopus入藏号 | 2-s2.0-85186956188 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://repository.uic.edu.cn/handle/39GCC9TT/11490 |
专题 | 理工科技学院 |
通讯作者 | Hu, Yue |
作者单位 | 1.Department of Neurology,Children’s Hospital of Chongqing Medical University,Chongqing,China 2.Department of Neonatology,Women’s Hospital,School of Medicine,Zhejiang University,Hangzhou,China 3.Guangdong Provincial Key Laboratory of Interdisciplinary Research and Application for Data Science,BNU-HKBU United International College,Zhuha,China 4.Ministry of Education Key Laboratory of Child Development and Disorders,Chongqing,China 5.National Clinical Research Center for Child Health and Disorders,Chongqing,China 6.China International Science and Technology Cooperation Base of Child Development and Critical Disorders,Chongqing,China 7.Chongqing Key Laboratory of Pediatrics,Chongqing,China |
推荐引用方式 GB/T 7714 | Xia, Xueqian,Zhang, Lingyu,Zheng, Haoet al. Clinical characteristics and prognosis of pediatric Listeria monocytogenes meningitis based on 10-year data from a large children's hospital in China[J]. Microbiology Spectrum, 2024, 12(3). |
APA | Xia, Xueqian, Zhang, Lingyu, Zheng, Hao, Peng, Xiaoling, Jiang, Li, & Hu, Yue. (2024). Clinical characteristics and prognosis of pediatric Listeria monocytogenes meningitis based on 10-year data from a large children's hospital in China. Microbiology Spectrum, 12(3). |
MLA | Xia, Xueqian,et al."Clinical characteristics and prognosis of pediatric Listeria monocytogenes meningitis based on 10-year data from a large children's hospital in China". Microbiology Spectrum 12.3(2024). |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论