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题名Clinical characteristics and prognosis of pediatric Listeria monocytogenes meningitis based on 10-year data from a large children's hospital in China
作者
发表日期2024-03-01
发表期刊Microbiology Spectrum
ISSN/eISSN2165-0497
卷号12期号:3
摘要

This study aims to summarize the clinical characteristics and prognosis of Listeria monocytogenes (LM) meningitis in children in Chongqing, China. A retrospective analysis of the clinical data and follow-up results of 20 LM meningitis patients admitted to the Children’s Hospital of Chongqing Medical University (CHCMU) from January 2012 to December 2022 was performed. The LM meningitis incidence rate was between 0 and 14.3 per 100,000 persons. The median age at onset was 8.98 months. There were five neonate cases, which all had perinatal abnormalities. Seven non-neonatal cases (7/15, 46.7%) had a documented history of contaminated food intake. One case had primary immunodeficiency. The most common symptoms were fever (20/20), altered consciousness (19/20), and vomiting (15/20). Seven cases had seizures, eight cases had cranial nerve involvement, eight cases had positive Babinski sign, and 10 cases had positive meningeal signs. The most common complications were hyponatremia (6/20), hypokalemia (6/20), respiratory failure (5/20), subdural effusion (3/20), and hydrocephalus (2/20). Treatment primarily involved monotherapy or combination therapy with meropenem (15/20) and ampicillin (10/20). Fifteen cases were treated with monotherapy or combination therapy using vancomycin. Twelve cases were successfully followed up from 10 months to 9 years and 6 months, and all had favorable long-term outcomes. LM meningitis incidence in children is low and with nonspecific clinical manifestations. Strengthening food hygiene and safety education, and avoiding infections during pregnancy are important to prevent LM infection in neonates and high-risk individuals. Meropenem and ampicillin are the preferred treatments. Early diagnosis and treatment can improve prognosis.

关键词children clinical characteristics KEYWORDS Listeria monocytogenes meningitis treatment
DOI10.1128/spectrum.03244-23
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收录类别SCIE
语种英语English
WOS研究方向Microbiology
WOS类目Microbiology
WOS记录号WOS:001151739800001
Scopus入藏号2-s2.0-85186956188
引用统计
文献类型期刊论文
条目标识符https://repository.uic.edu.cn/handle/39GCC9TT/11490
专题理工科技学院
通讯作者Hu, Yue
作者单位
1.Department of Neurology,Children’s Hospital of Chongqing Medical University,Chongqing,China
2.Department of Neonatology,Women’s Hospital,School of Medicine,Zhejiang University,Hangzhou,China
3.Guangdong Provincial Key Laboratory of Interdisciplinary Research and Application for Data Science,BNU-HKBU United International College,Zhuha,China
4.Ministry of Education Key Laboratory of Child Development and Disorders,Chongqing,China
5.National Clinical Research Center for Child Health and Disorders,Chongqing,China
6.China International Science and Technology Cooperation Base of Child Development and Critical Disorders,Chongqing,China
7.Chongqing Key Laboratory of Pediatrics,Chongqing,China
推荐引用方式
GB/T 7714
Xia, Xueqian,Zhang, Lingyu,Zheng, Haoet al. Clinical characteristics and prognosis of pediatric Listeria monocytogenes meningitis based on 10-year data from a large children's hospital in China[J]. Microbiology Spectrum, 2024, 12(3).
APA Xia, Xueqian, Zhang, Lingyu, Zheng, Hao, Peng, Xiaoling, Jiang, Li, & Hu, Yue. (2024). Clinical characteristics and prognosis of pediatric Listeria monocytogenes meningitis based on 10-year data from a large children's hospital in China. Microbiology Spectrum, 12(3).
MLA Xia, Xueqian,et al."Clinical characteristics and prognosis of pediatric Listeria monocytogenes meningitis based on 10-year data from a large children's hospital in China". Microbiology Spectrum 12.3(2024).
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