Network pharmacology and bioinformatics to identify the molecular mechanisms of Gleditsiae Spina against colorectal cancer

doi:10.1016/j.crtox.2023.100139

科研成果详情

题名	Network pharmacology and bioinformatics to identify the molecular mechanisms of Gleditsiae Spina against colorectal cancer
作者	Wu，Yingzi 1,2; Luo，Jinhai 1,2; Xu，Baojun1
发表日期	2023
发表期刊	Current Research in Toxicology
卷号	5
摘要	Objective: In this study, network pharmacology, bioinformatics and molecular docking were used to explore the active phytochemicals, hub genes, and potential molecular mechanisms of Gleditsiae Spina in treating of colorectal cancer. Methods: The targets of Gleditsiae Spina, and targets related to CRC were derived from databases. We identified the hub genes for Gleditsiae Spina anti-colorectal cancer following the protein–protein-interaction (PPI) network. Furthermore, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment were used to analyze the hub genes from a macro perspective. Finally, we verified the hub genes by molecular docking, GEPIA, HPA, and starBase database. Results: We identified nine active phytochemicals and 36 intersection targets. The GO enrichment analysis results showed that Gleditsiae Spina may be involved in gene targets affecting multiple biological processes, including response to radiation, response to ionizing radiation, cyclin-dependent protein kinase holoenzyme complex, serine/threonine protein kinase complex, cyclin-dependent protein serine/threonine kinase regulator activity and protein kinase regulator activity. KEGG enrichment analysis results indicated that the P53 signaling pathway, IL-17 signaling pathway, Toll-like receptor signaling pathway, PI3K-Akt signaling pathway, and JAK-STAT signaling pathway were mainly related to the effect of Gleditsiae Spina on colorectal cancer. Molecular docking analysis suggested that the active phytochemicals of Gleditsiae Spina could combine well with hub genes (PTGS1, PIK3CG, CCND1, CXCL8 and ADRB2). Conclusion: This study provides clues for further study of anti-CRC phytochemicals as well as their mechanisms of provides a basis for their development model.
关键词	Active phytochemicals Bioinformatics Colorectal cancer Gleditsiae Spina Molecular docking Network pharmacology
DOI	10.1016/j.crtox.2023.100139
URL	查看来源
语种	英语English
Scopus入藏号	2-s2.0-85183655554
引用统计	被引频次：7[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://repository.uic.edu.cn/handle/39GCC9TT/11595
专题	北师香港浸会大学
通讯作者	Xu，Baojun
作者单位	1.Guangdong Provincial Key Laboratory IRADS and Department of Life Sciences,BNU-HKBU United International College,Zhuhai,519087,China 2.School of Chinese Medicine,Hong Kong Baptist University,Hong Kong
第一作者单位	北师香港浸会大学
通讯作者单位	北师香港浸会大学
推荐引用方式 GB/T 7714	Wu，Yingzi,Luo，Jinhai,Xu，Baojun. Network pharmacology and bioinformatics to identify the molecular mechanisms of Gleditsiae Spina against colorectal cancer[J]. Current Research in Toxicology, 2023, 5.
APA	Wu，Yingzi, Luo，Jinhai, & Xu，Baojun. (2023). Network pharmacology and bioinformatics to identify the molecular mechanisms of Gleditsiae Spina against colorectal cancer. Current Research in Toxicology, 5.
MLA	Wu，Yingzi,et al."Network pharmacology and bioinformatics to identify the molecular mechanisms of Gleditsiae Spina against colorectal cancer". Current Research in Toxicology 5(2023).