科研成果详情

题名3,4′,5-Trimethoxy-trans-stilbene ameliorates hepatic insulin resistance and oxidative stress in diabetic obese mice through insulin and Nrf2 signaling pathways
作者
发表日期2024-02-15
发表期刊Food and Function
ISSN/eISSN2042-6496
卷号15期号:6页码:2996-3007
摘要Resveratrol has profound benefits against diabetes. However, whether its methylated derivative 3,4′,5-trimethoxy-trans-stilbene (3,4′,5-TMS) also plays a protective role in glucose metabolism is not characterized. We aimed to study the anti-diabetic effects of 3,4′,5-TMS in vitro and in vivo. Insulin-resistant HepG2 cells (IR-HepG2) were induced by high glucose plus dexamethasone whilst six-week-old male C57BL/6J mice received a 60 kcal% fat diet for 14 weeks to establish an obese diabetic model. 3,4′,5-TMS did not reduce the cell viability of IR-HepG2 cells at concentrations of 0.5 and 1 μM, which enhanced the capability of glycogen synthesis and glucose consumption in IR-HepG2 cells. Four-week oral administration of 3,4′,5-TMS at 10 mg kg day ameliorated insulin sensitivity and glucose tolerance of diet-induced obese (DIO) mice. 3,4′,5-TMS activated the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) pathway by inhibiting phosphorylation of insulin receptor substrate (IRS)-1 at Ser307 and increasing the protein levels of IRS-1 and IRS-2 to restore the insulin signaling pathway in diabetes. 3,4′,5-TMS also upregulated the phosphorylation of glycogen synthase kinase 3 beta (GSK3β) at Ser9. 3,4′,5-TMS suppressed oxidative stress by increasing the protein levels of nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1) and NAD(P)H : quinone oxidoreductase 1 (NQO1) and antioxidant enzyme activity. In summary, 3,4′,5-TMS alleviated hepatic insulin resistance in vitro and in vivo, by the activation of the insulin signaling pathway, accomplished by the suppression of oxidative stress.
DOI10.1039/d3fo04158a
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语种英语English
Scopus入藏号2-s2.0-85186457750
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被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符https://repository.uic.edu.cn/handle/39GCC9TT/11633
专题北师香港浸会大学
通讯作者Xu,Baojun
作者单位
1.Institute of Chinese Medical Sciences,State Key Laboratory of Quality Research in Chinese Medicine,University of Macau,SAR,Macao
2.Department of Pharmacy,Abdul Wali Khan University Mardan,Mardan,23200,Pakistan
3.Food Science and Technology Program,BNU-HKBU United International College,Zhuhai,Guangdong,China
通讯作者单位北师香港浸会大学
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GB/T 7714
Tan,Yi,Zhou,Chunxiu,Miao,Lingchaoet al. 3,4′,5-Trimethoxy-trans-stilbene ameliorates hepatic insulin resistance and oxidative stress in diabetic obese mice through insulin and Nrf2 signaling pathways[J]. Food and Function, 2024, 15(6): 2996-3007.
APA Tan,Yi., Zhou,Chunxiu., Miao,Lingchao., Zhang,Xutao., Khan,Haroon., .. & Cheang,Wai San. (2024). 3,4′,5-Trimethoxy-trans-stilbene ameliorates hepatic insulin resistance and oxidative stress in diabetic obese mice through insulin and Nrf2 signaling pathways. Food and Function, 15(6), 2996-3007.
MLA Tan,Yi,et al."3,4′,5-Trimethoxy-trans-stilbene ameliorates hepatic insulin resistance and oxidative stress in diabetic obese mice through insulin and Nrf2 signaling pathways". Food and Function 15.6(2024): 2996-3007.
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