CGP 52608-induced cyst formation in dinoflagellates: Possible involvement of a nuclear receptor for melatonin

doi:10.1111/j.1600-079x.1996.tb00276.x

科研成果详情

题名	CGP 52608-induced cyst formation in dinoflagellates: Possible involvement of a nuclear receptor for melatonin
作者	Tsim，Siu Tai; Wong，Joseph T.Y.; Wong，Yung H.
发表日期	1996
发表期刊	Journal of Pineal Research
ISSN/eISSN	0742-3098
卷号	21 期号:2 页码:101-107
摘要	Melatonin has been shown to regulate gene transcription through RZR/ROR nuclear receptors in mammalian cells. Thiazolidine dione CGP 52608 is a selective agonist of RZR/ROR receptors with little or no affinity for the cell surface G protein-coupled melatonin receptors. In this study, we addressed whether nuclear signaling may be involved in indoleamine-induced encystment of the unicellular dinoflagellates by examining their responses to CGP 52608. Three species of dinoflagellates (Alexandrium catenella, Amphidinium carterae, and Crypthecodinium cohnii) encysted in the presence of CGP 52608 and the responses were reversible and dose-dependent. Since a previous study has implicated the involvement of G proteins in mediating indoleamine-induced encystment of dinoflagellates, we explored the possibility of cross-talks between G protein-dependent and nuclear signaling pathways. The responses of A. catenella to either mastoparan (a direct activator of mammalian G proteins) or indoleamines were assessed in the presence or absence of CGP 52608. Interestingly, CGP 52608 synergized with either indoleamines or mastoparan to produce a more rapid encystment response. These findings suggest that nuclear signaling may be involved in the indoleamine-induced encystment of dinoflagellates. © Munksgaard.
关键词	5-methoxytryptamine CGP 52608 Dinoflagellate Encystment Melatonin Nuclear receptor
DOI	10.1111/j.1600-079x.1996.tb00276.x
URL	查看来源
语种	英语English
Scopus入藏号	2-s2.0-0030226698
引用统计
文献类型	期刊论文
条目标识符	https://repository.uic.edu.cn/handle/39GCC9TT/11708
专题	个人在本单位外知识产出
通讯作者	Wong，Yung H.
作者单位	Department of Biology,Hong Kong University of Science and Technology,Clear Water Bay,Kowloon,Hong Kong
推荐引用方式 GB/T 7714	Tsim，Siu Tai,Wong，Joseph T.Y.,Wong，Yung H. CGP 52608-induced cyst formation in dinoflagellates: Possible involvement of a nuclear receptor for melatonin[J]. Journal of Pineal Research, 1996, 21(2): 101-107.
APA	Tsim，Siu Tai, Wong，Joseph T.Y., & Wong，Yung H. (1996). CGP 52608-induced cyst formation in dinoflagellates: Possible involvement of a nuclear receptor for melatonin. Journal of Pineal Research, 21(2), 101-107.
MLA	Tsim，Siu Tai,et al."CGP 52608-induced cyst formation in dinoflagellates: Possible involvement of a nuclear receptor for melatonin". Journal of Pineal Research 21.2(1996): 101-107.