Effects of dibutyryl camp and bacterial toxins on indoleamine-induced encystment of dinoflagellates

doi:10.1159/000109170

科研成果详情

题名	Effects of dibutyryl camp and bacterial toxins on indoleamine-induced encystment of dinoflagellates
作者	Tsim，Siu Tai; Wong，Joseph T.Y.; Wong，Yung H.
发表日期	1996
发表期刊	NeuroSignals
ISSN/eISSN	1424-862X
卷号	5 期号:1 页码:22-29
摘要	Dinoflagellates are the causative agents of red tides with worldwide occurrence and can be induced to encyst by indoleamines such as melatonin and 5-methoxytryptamine (5-MOT). This biological response may be mediated via indoleamine-binding proteins or receptors. Here we report the initial characterization of the signal transduction mechanisms by which indoleamines induce encystment of dinoflagellates. In particular, we explored the possible involvement of G proteins and cAMP in cyst formation. Both melatonin and 5-MOT promoted the encystment of Gonyaulax tamarensis and Crypthecodinium cohnii. Exposure of dinoflagellates to dibutyryl cAMP, which directly activates cAMP-dependent pathways, did not affect the ability of indoleamines to promote encystment. However, dibutyryl cAMP dose-dependently diminished the indoleamine-induced suppression of cell growth. Exposure of dinoflagellates to the bacterial toxins from Vibrio cholerae and Bordetella pertussis had no effect on the indoleamine-induced encystment response, indicating the lack of involvement of G or G-like proteins. Moreover, [P]ADP ribosylation of dinoflagellate membranes by either toxin failed to identify substrate proteins. These results suggest that although the indoleamine-induced encystment of dinoflagellates may involve a G-protein-coupled signal transduction pathway, the identity of the G protein concerned may be distinct from those that regulate adenylyl cyclases in mammalian cells. © 1996 S. Karger AG, Basel.
关键词	cAMP Dinoflagellate G proteins Melatonin Signal transduction
DOI	10.1159/000109170
URL	查看来源
语种	英语English
Scopus入藏号	2-s2.0-0029927873
引用统计
文献类型	期刊论文
条目标识符	https://repository.uic.edu.cn/handle/39GCC9TT/11709
专题	个人在本单位外知识产出
通讯作者	Wong，Yung H.
作者单位	Department of Biology,Hong Kong University of Science and Technology,Kowloon,Hong Kong
推荐引用方式 GB/T 7714	Tsim，Siu Tai,Wong，Joseph T.Y.,Wong，Yung H. Effects of dibutyryl camp and bacterial toxins on indoleamine-induced encystment of dinoflagellates[J]. NeuroSignals, 1996, 5(1): 22-29.
APA	Tsim，Siu Tai, Wong，Joseph T.Y., & Wong，Yung H. (1996). Effects of dibutyryl camp and bacterial toxins on indoleamine-induced encystment of dinoflagellates. NeuroSignals, 5(1), 22-29.
MLA	Tsim，Siu Tai,et al."Effects of dibutyryl camp and bacterial toxins on indoleamine-induced encystment of dinoflagellates". NeuroSignals 5.1(1996): 22-29.