Stimulation of cAMP accumulation by the cloned Xenopus melatonin receptor through Gi and Gz proteins

doi:10.1016/0014-5793(95)00963-A

科研成果详情

题名	Stimulation of cAMP accumulation by the cloned Xenopus melatonin receptor through Gi and Gz proteins
作者	Yung，Lisa Y.; Tsim，Siu Tai; Wong，Yung H.
发表日期	1995-09-18
发表期刊	FEBS Letters
ISSN/eISSN	0014-5793
卷号	372 期号:1 页码:99-102
摘要	The Xenopus melatonin receptor was expressed in human embryonic kidney 293 cells and assayed for cAMP accumulation. In transfected 293 cells expressing the melatonin receptor, melatonin dose-dependently inhibited the endogenous adenylyl cyclases. In contrast, melatonin stimulated the accumulation of cAMP in cells co-expressing the type II adenylyl cyclase. Both the inhibitory and stimulatory responses to melatonin were mediated via G-like proteins as they were blocked by pertussis toxin. Upon co-transfection with the α subunit of G, the ability of melatonin to regulate both type II and the endogenous adenylyl cyclases became refractory to pertussis toxin, indicating that the melatonin receptor can also couple to G. However, other pertussis toxin-insensitive G proteins such as G, G and G were unable to interact with the melatonin receptor. © 1995.
关键词	Adenylyl cyclase G protein Melatonin receptor Signal transduction
DOI	10.1016/0014-5793(95)00963-A
URL	查看来源
语种	英语English
Scopus入藏号	2-s2.0-0029145187
引用统计	被引频次：72[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://repository.uic.edu.cn/handle/39GCC9TT/11710
专题	个人在本单位外知识产出
作者单位	Department of Biology, Hong Kong University of Science and Technology, Clear Water Bay, Kowloonm, Hong Kong
推荐引用方式 GB/T 7714	Yung，Lisa Y.,Tsim，Siu Tai,Wong，Yung H. Stimulation of cAMP accumulation by the cloned Xenopus melatonin receptor through Gi and Gz proteins[J]. FEBS Letters, 1995, 372(1): 99-102.
APA	Yung，Lisa Y., Tsim，Siu Tai, & Wong，Yung H. (1995). Stimulation of cAMP accumulation by the cloned Xenopus melatonin receptor through Gi and Gz proteins. FEBS Letters, 372(1), 99-102.
MLA	Yung，Lisa Y.,et al."Stimulation of cAMP accumulation by the cloned Xenopus melatonin receptor through Gi and Gz proteins". FEBS Letters 372.1(1995): 99-102.