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题名Efficacy, safety, and tolerability of adjunctive Lacosamide therapy for focal seizures in young children aged ≥1 month to ≤4 years: A real-world study
作者
发表日期2024-08-01
发表期刊CNS Neuroscience and Therapeutics
ISSN/eISSN1755-5930
卷号30期号:8
摘要

Aims: To evaluate the efficacy, safety, and tolerability of adjunctive lacosamide therapy against focal seizures in young children (1 month – 4 years). Methods: This non-randomized, open-label, and self-controlled real-world study included 105 children (1 month–4 years) with focal seizures treated with adjunctive lacosamide therapy at Children's Hospital of Chongqing Medical University. Results: (1) The 50% response rates at 3, 6, 9, and 12 months of follow-up were 58.1%, 61.0%, 57.1%, and 56.2%, while the seizure-free rates were 27.6%, 34.3%, 32.4%, and 37.1%, respectively. The 50% response rate of the first addition of lacosamide for focal seizures was much higher than the second and later added treatment at 3 months (p = 0.038). After 1 year of follow-up, these children showed an improvement in neurodevelopmental levels (p < 0.05). (2) Lacosamide retention rate was 72.7% (64/88) after 1 year of follow-up. Lack of efficacy and serious adverse events were independent risk factors for the lacosamide retention rate. (3) During adjunctive lacosamide therapy, 13 (12.4%) patients reported adverse events and five (4.7%) patients withdrew due to adverse events, including vomiting drowsiness, ataxia (0.94%), neck itching with eczema (0.94%), irritability (1.88%), and gastrointestinal discomfort (0.94%). Conclusion: Adjunctive lacosamide therapy was effective, safe, and well-tolerated in young Chinese children with focal seizures in this study.

关键词adjunctive therapy children focal seizures lacosamide
DOI10.1111/cns.14917
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收录类别SCIE
语种英语English
WOS研究方向Neurosciences & Neurology ; Pharmacology & Pharmacy
WOS类目Neurosciences ; Pharmacology & Pharmacy
WOS记录号WOS:001287989100001
Scopus入藏号2-s2.0-85200891436
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文献类型期刊论文
条目标识符https://repository.uic.edu.cn/handle/39GCC9TT/11732
专题理工科技学院
通讯作者Hu, Yue
作者单位
1.Chongqing Med Univ, Childrens Hosp,Big Data Engn Ctr, Natl Clin Res Ctr Child Hlth & Disorders,Chongqing, Dept Gastroenterol,Minist Educ,Key Lab Child Dev &, Chongqing, Peoples R China
2.Guangdong Provincial Key Laboratory of Interdisciplinary Research and Application for Data Science,BNU-HKBU United International College,Zhuhai,China
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GB/T 7714
Yang, Lu,Liu, Yuhang,Deng, Yuet al. Efficacy, safety, and tolerability of adjunctive Lacosamide therapy for focal seizures in young children aged ≥1 month to ≤4 years: A real-world study[J]. CNS Neuroscience and Therapeutics, 2024, 30(8).
APA Yang, Lu., Liu, Yuhang., Deng, Yu., Peng, Xiaoling., Hu, Qiao., .. & Hu, Yue. (2024). Efficacy, safety, and tolerability of adjunctive Lacosamide therapy for focal seizures in young children aged ≥1 month to ≤4 years: A real-world study. CNS Neuroscience and Therapeutics, 30(8).
MLA Yang, Lu,et al."Efficacy, safety, and tolerability of adjunctive Lacosamide therapy for focal seizures in young children aged ≥1 month to ≤4 years: A real-world study". CNS Neuroscience and Therapeutics 30.8(2024).
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