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题名Insights into the anticancer effects of galangal and galangin: A comprehensive review
作者
发表日期2024-12-01
发表期刊Phytomedicine
ISSN/eISSN0944-7113
卷号135
摘要

Backgrounds: Cancer continues to be the leading cause of death worldwide, significantly impacting both health and the economy. Natural products have emerged as promising sources for the development of new anticancer drugs, with galangal and their active ingredient, galangin, garnering substantial interest. Purpose: This study summarizes recent findings on the anticancer properties of galangal and galangin, highlighting their potential to target various cancer types. Methods: We systematically searched the literature across PubMed, Web of Science, and Google Scholar, using keywords such as “Alpinia officinarum,” “Alpinia galanga”, “galangal,” and “galangin.” This thorough approach allowed us to gather and compile a comprehensive collection of existing research on the topic. Results: This article provided a thorough analysis of the distribution of galangal, the methods used to extract the active compounds of galangal, and the anticancer properties of both galangin and galangal. It is important to note that galangal and galangin primarily function by regulating the signaling pathways of PI3K/Akt, MAPK, AMPK, p53, NF-κB, and Ras/RAF/MEK/ERK, which in turn triggers apoptosis, autophagy, and ROS while preventing the migration and invasion of cancer cells. We also discussed their toxicity, bioavailability, and clinical uses. Conclusion: In conclusion, galangal extract and galangin have a lot of promise for treating cancer. It is anticipated that this review will further advance the use of galangal extract and galangin as potential cancer treatment medications. Moreover, the discovery and development of drugs based on galangal has enormous potential for the therapy of cancer.

关键词Alpinia galanga (L.) Willd Alpinia officinarum Hance Anticancer Ethnobotany uses Galangal Galangin Pathway
DOI10.1016/j.phymed.2024.156085
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收录类别SCIE
语种英语English
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
WOS类目Plant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS记录号WOS:001368674300001
Scopus入藏号2-s2.0-85205150928
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符https://repository.uic.edu.cn/handle/39GCC9TT/12059
专题理工科技学院
通讯作者Xu, Baojun
作者单位
1.Food Science and Technology Program,Department of Life Sciences,BNU-HKBU United International College,Zhuhai,519087,China
2.School of Chinese Medicine,Hong Kong Baptist University,Hong Kong,China
第一作者单位北师香港浸会大学
通讯作者单位北师香港浸会大学
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GB/T 7714
Wu, Yingzi,Luo, Jinhai,Xu, Baojun. Insights into the anticancer effects of galangal and galangin: A comprehensive review[J]. Phytomedicine, 2024, 135.
APA Wu, Yingzi, Luo, Jinhai, & Xu, Baojun. (2024). Insights into the anticancer effects of galangal and galangin: A comprehensive review. Phytomedicine, 135.
MLA Wu, Yingzi,et al."Insights into the anticancer effects of galangal and galangin: A comprehensive review". Phytomedicine 135(2024).
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