发表状态 | 已发表Published |
题名 | Insights into the anticancer effects of galangal and galangin: A comprehensive review |
作者 | |
发表日期 | 2024-12-01 |
发表期刊 | Phytomedicine
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ISSN/eISSN | 0944-7113 |
卷号 | 135 |
摘要 | Backgrounds: Cancer continues to be the leading cause of death worldwide, significantly impacting both health and the economy. Natural products have emerged as promising sources for the development of new anticancer drugs, with galangal and their active ingredient, galangin, garnering substantial interest. Purpose: This study summarizes recent findings on the anticancer properties of galangal and galangin, highlighting their potential to target various cancer types. Methods: We systematically searched the literature across PubMed, Web of Science, and Google Scholar, using keywords such as “Alpinia officinarum,” “Alpinia galanga”, “galangal,” and “galangin.” This thorough approach allowed us to gather and compile a comprehensive collection of existing research on the topic. Results: This article provided a thorough analysis of the distribution of galangal, the methods used to extract the active compounds of galangal, and the anticancer properties of both galangin and galangal. It is important to note that galangal and galangin primarily function by regulating the signaling pathways of PI3K/Akt, MAPK, AMPK, p53, NF-κB, and Ras/RAF/MEK/ERK, which in turn triggers apoptosis, autophagy, and ROS while preventing the migration and invasion of cancer cells. We also discussed their toxicity, bioavailability, and clinical uses. Conclusion: In conclusion, galangal extract and galangin have a lot of promise for treating cancer. It is anticipated that this review will further advance the use of galangal extract and galangin as potential cancer treatment medications. Moreover, the discovery and development of drugs based on galangal has enormous potential for the therapy of cancer. |
关键词 | Alpinia galanga (L.) Willd Alpinia officinarum Hance Anticancer Ethnobotany uses Galangal Galangin Pathway |
DOI | 10.1016/j.phymed.2024.156085 |
URL | 查看来源 |
收录类别 | SCIE |
语种 | 英语English |
WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine |
WOS类目 | Plant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy |
WOS记录号 | WOS:001368674300001 |
Scopus入藏号 | 2-s2.0-85205150928 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://repository.uic.edu.cn/handle/39GCC9TT/12059 |
专题 | 理工科技学院 |
通讯作者 | Xu, Baojun |
作者单位 | 1.Food Science and Technology Program,Department of Life Sciences,BNU-HKBU United International College,Zhuhai,519087,China 2.School of Chinese Medicine,Hong Kong Baptist University,Hong Kong,China |
第一作者单位 | 北师香港浸会大学 |
通讯作者单位 | 北师香港浸会大学 |
推荐引用方式 GB/T 7714 | Wu, Yingzi,Luo, Jinhai,Xu, Baojun. Insights into the anticancer effects of galangal and galangin: A comprehensive review[J]. Phytomedicine, 2024, 135. |
APA | Wu, Yingzi, Luo, Jinhai, & Xu, Baojun. (2024). Insights into the anticancer effects of galangal and galangin: A comprehensive review. Phytomedicine, 135. |
MLA | Wu, Yingzi,et al."Insights into the anticancer effects of galangal and galangin: A comprehensive review". Phytomedicine 135(2024). |
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