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题名Machine learning based predictive analysis of DNA cleavage induced by diverse nanomaterials
作者
发表日期2024-12-01
发表期刊Scientific Reports
ISSN/eISSN2045-2322
卷号14期号:1
摘要

DNA cleavage by nanomaterials has the potential to be utilized as an innovative tool for gene editing. Numerous nanomaterials exhibiting DNA cleavage properties have been identified and cataloged. Yet, the exploitation of property data through data-driven machine-learning approaches remains unexplored. A database was developed, compiling thirty distinctive characteristics, encompassing physical and chemical properties, as well as experimental conditions of nanomaterials that have demonstrated DNA cleavage capability such as in articles published over the past two decades. The DNA cleavage effect and efficiency of nanomaterials were predicted using machine learning algorithms such as support vector machines, deep neural networks, and random forest, and a classification accuracy of 0.93 for the cleavage effect was achieved. Moreover, the potential of utilizing larger datasets to enhance the predictive capacity of models was discussed. The findings indicate the feasibility of predicting nanomaterial properties based on experimental data. Evaluating the performance and effectiveness of the machine learning models trained using the existing data can furnish valuable insights for future materials research endeavors, especially for the design of DNA cleavage with specific sites.

DOI10.1038/s41598-024-73140-1
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收录类别SCIE
语种英语English
WOS研究方向Science & Technology - Other Topics
WOS类目Multidisciplinary Sciences
WOS记录号WOS:001317591600014
Scopus入藏号2-s2.0-85204426213
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符https://repository.uic.edu.cn/handle/39GCC9TT/12060
专题北师香港浸会大学
通讯作者Wu, Pan
作者单位
1.College of Resources and Environmental Engineering,Guizhou University,Guiyang,550025,China
2.Key Laboratory of Karst Georesources and Environment,Ministry of Education,Guiyang,550025,China
3.School of Environment,Jinan University,Guangzhou,510632,China
4.Environmental Science Program,Department of Life Sciences,Beijing Normal University-Hong Kong Baptist University United International College,Zhuhai,No. 2000 Jintong Road, Tangjiawan, Guangdong,519087,China
5.College of Chemistry and Materials Science,Jinan University,Guangzhou,510632,China
6.College of Life Science and Technology,Jinan University,Guangzhou,510632,China
推荐引用方式
GB/T 7714
Niu, Jie,Wang, Xufeng,Chen, Jianglinget al. Machine learning based predictive analysis of DNA cleavage induced by diverse nanomaterials[J]. Scientific Reports, 2024, 14(1).
APA Niu, Jie., Wang, Xufeng., Chen, Jiangling., Zhao, Yingcan., Chen, Xiaohui., .. & Wu, Pan. (2024). Machine learning based predictive analysis of DNA cleavage induced by diverse nanomaterials. Scientific Reports, 14(1).
MLA Niu, Jie,et al."Machine learning based predictive analysis of DNA cleavage induced by diverse nanomaterials". Scientific Reports 14.1(2024).
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