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题名Mechanical interaction between a hydrogel and an embedded cell in biomicrofluidic applications
作者
发表日期2025-03-01
发表期刊Biomicrofluidics
ISSN/eISSN1932-1058
卷号19期号:2
摘要

Thanks to their softness, biocompatibility, porosity, and ready availability, hydrogels are commonly used in microfluidic assays and organ-on-chip devices as a matrix for cells. They not only provide a supporting scaffold for the differentiating cells and the developing organoids, but also serve as the medium for transmitting oxygen, nutrients, various chemical factors, and mechanical stimuli to the cells. From a bioengineering viewpoint, the transmission of forces from fluid perfusion to the cells through the hydrogel is critical to the proper function and development of the cell colony. In this paper, we develop a poroelastic model to represent the fluid flow through a hydrogel containing a biological cell modeled as a hyperelastic inclusion. In geometries representing shear and normal flows that occur frequently in microfluidic experiments, we use finite-element simulations to examine how the perfusion engenders interstitial flow in the gel and displaces and deforms the embedded cell. The results show that pressure is the most important stress component in moving and deforming the cell, and the model predicts the velocity in the gel and stress transmitted to the cell that is comparable to in vitro and in vivo data. This work provides a computational tool to design the geometry and flow conditions to achieve optimal flow and stress fields inside the hydrogels and around the cell.

DOI10.1063/5.0263344
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收录类别SCIE
语种英语English
WOS研究方向Biochemistry & Molecular Biology ; Biophysics ; Science & Technology - Other TopicsPhysics
WOS类目Biochemical Research Methods ; Biophysics Nanoscience & Nanotechnology ; Physics, Fluids & Plasmas
WOS记录号WOS:001459337400001
Scopus入藏号2-s2.0-105002561053
引用统计
文献类型期刊论文
条目标识符https://repository.uic.edu.cn/handle/39GCC9TT/12822
专题北师香港浸会大学
通讯作者Feng, James J.
作者单位
1.Department of Chemical and Biological Engineering,University of British Columbia,Vancouver,V6T 1Z3,Canada
2.Research Center for Mathematics,Advanced Institute of Natural Sciences,Beijing Normal University,Zhuhai,519087,China
3.Guangdong Provincial,Zhuhai Key Laboratory,IRADS,BNU-HKBU,United International College,Zhuhai,519087,China
4.Department of Mathematics,Virginia Tech,Blacksburg,24061,United States
5.Department of Mathematics,University of British Columbia,Vancouver,V6T 1Z2,Canada
推荐引用方式
GB/T 7714
Li, Lei,Zhang, Jiaqi,Yue, Pengtaoet al. Mechanical interaction between a hydrogel and an embedded cell in biomicrofluidic applications[J]. Biomicrofluidics, 2025, 19(2).
APA Li, Lei, Zhang, Jiaqi, Yue, Pengtao, & Feng, James J. (2025). Mechanical interaction between a hydrogel and an embedded cell in biomicrofluidic applications. Biomicrofluidics, 19(2).
MLA Li, Lei,et al."Mechanical interaction between a hydrogel and an embedded cell in biomicrofluidic applications". Biomicrofluidics 19.2(2025).
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