发表状态 | 已发表Published |
题名 | Prophage Hunter: an integrative hunting tool for active prophages |
作者 | |
发表日期 | 2019-07-01 |
发表期刊 | Nucleic Acids Research
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ISSN/eISSN | 0305-1048 |
卷号 | 47期号:W1页码:W74-W80 |
摘要 | Identifying active prophages is critical for studying coevolution of phage and bacteria, investigating phage physiology and biochemistry, and engineering designer phages for diverse applications. We present Prophage Hunter, a tool aimed at hunting for active prophages from whole genome assembly of bacteria. Combining sequence similarity-based matching and genetic features-based machine learning classification, we developed a novel scoring system that exhibits higher accuracy than current tools in predicting active prophages on the validation datasets. The option of skipping similarity matching is also available so that there's higher chance for novel phages to be discovered. Prophage Hunter provides a one-stop web service to extract prophage genomes from bacterial genomes, evaluate the activity of the prophages, identify phylogenetically related phages, and annotate the function of phage proteins. Prophage Hunter is freely available at https://pro-hunter.bgi.com/. |
DOI | 10.1093/nar/gkz380 |
URL | 查看来源 |
收录类别 | SCIE |
语种 | 英语English |
WOS研究方向 | Biochemistry & Molecular Biology |
WOS类目 | Biochemistry & Molecular Biology |
WOS记录号 | WOS:000475901600011 |
Scopus入藏号 | 2-s2.0-85069234057 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://repository.uic.edu.cn/handle/39GCC9TT/13138 |
专题 | 个人在本单位外知识产出 |
通讯作者 | Xiao, Minfeng |
作者单位 | 1.BGI-Shenzhen,Shenzhen,518083,China 2.China National Genebank,BGI-Shenzhen,Shenzhen,518120,China 3.Department of Biomedical Engineering,Duke University,Durham,27708,United States 4.Center for Genomic and Computational Biology,Duke University,Durham,27708,United States 5.Department of Molecular Genetics and Microbiology,Duke University School of Medicine,Durham,27708,United States 6.Department of Clinical Laboratory,Xiangya Hospital,Central South University,Changsha,410008,China 7.South China University of Technology,Guangzhou, Guangdong,510640,China 8.Department of Basic Medical Sciences,Qingdao University,Qingdao,266071,China |
推荐引用方式 GB/T 7714 | Song, Wenchen,Sun, Hai Xi,Zhang, Carolynet al. Prophage Hunter: an integrative hunting tool for active prophages[J]. Nucleic Acids Research, 2019, 47(W1): W74-W80. |
APA | Song, Wenchen., Sun, Hai Xi., Zhang, Carolyn., Cheng, Li., Peng, Ye., .. & Xiao, Minfeng. (2019). Prophage Hunter: an integrative hunting tool for active prophages. Nucleic Acids Research, 47(W1), W74-W80. |
MLA | Song, Wenchen,et al."Prophage Hunter: an integrative hunting tool for active prophages". Nucleic Acids Research 47.W1(2019): W74-W80. |
条目包含的文件 | 条目无相关文件。 |
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