Stabilizing SiPM output with adaptive temperature compensation in portable real-time PCR devices

doi:10.1016/j.isatra.2025.04.016

科研成果详情

题名	Stabilizing SiPM output with adaptive temperature compensation in portable real-time PCR devices
作者	Li，Gui Ping 1; Ding，Wei 2; Liang，Wen Jing 3; Shi，Yu 2
发表日期	2025-07-01
发表期刊	ISA Transactions
ISSN/eISSN	0019-0578
卷号	162 页码:144-149
摘要	Real-time Polymerase Chain Reaction (PCR) technology is essential in clinical pathogen measurement due to its high sensitivity, specificity, and accuracy. Portable real-time PCR instruments, known for their quick response, mobility, and efficiency, are crucial for controlling emerging infectious diseases at the grassroots level. Silicon photomultipliers (SiPMs), with their high gain, sensitivity, low bias voltage, magnetic field insensitivity, and compactness, are widely used in various applications, including real-time PCR instruments. However, the gain of SiPM is temperature-dependent, which affects performance stability. In grassroots measurement environments, inadequate heat dissipation during equipment operation can alter SiPM working temperatures, impacting performance. To address this, we propose an innovative technique using a pair of Polymethyl Methacrylate(PMMA) polymer reference samples to stabilize SiPM output against temperature variations. This method effectively controls SiPM output fluctuations within 1%, even with temperature changes exceeding 10C, enhancing the stability, portability, and cost-effectiveness of fluorescence PCR instrument optical systems.
关键词	High gain Polymethyl Methacrylate Real-time PCR Silicon photo-multiplier Temperature compensation
DOI	10.1016/j.isatra.2025.04.016
URL	查看来源
语种	英语English
Scopus入藏号	2-s2.0-105003825482
引用统计
文献类型	期刊论文
条目标识符	https://repository.uic.edu.cn/handle/39GCC9TT/13256
专题	北师香港浸会大学
通讯作者	Ding，Wei
作者单位	1.Department of Computer Science and Technology,Beijing Normal University-Hong Kong Baptist University United International College,Zhuhai,519087,China 2.Faculty of Electrical Engineering and Automation,Changshu Institute of Technology,Changshu,215500,China 3.Hema Medical Instrument Co.,Ltd,Zhuhai,519087,China
第一作者单位	北师香港浸会大学
推荐引用方式 GB/T 7714	Li，Gui Ping,Ding，Wei,Liang，Wen Jinget al. Stabilizing SiPM output with adaptive temperature compensation in portable real-time PCR devices[J]. ISA Transactions, 2025, 162: 144-149.
APA	Li，Gui Ping, Ding，Wei, Liang，Wen Jing, & Shi，Yu. (2025). Stabilizing SiPM output with adaptive temperature compensation in portable real-time PCR devices. ISA Transactions, 162, 144-149.
MLA	Li，Gui Ping,et al."Stabilizing SiPM output with adaptive temperature compensation in portable real-time PCR devices". ISA Transactions 162(2025): 144-149.