发表状态 | 已发表Published |
题名 | Telomerase inhibitory effects of red pigment rubropunctatin and statin monacolin l isolated from red yeast rice |
作者 | |
发表日期 | 2017-05-01 |
发表期刊 | Genes
![]() |
ISSN/eISSN | 2073-4425 |
卷号 | 8期号:5 |
摘要 | In addition to the cholesterol-lowering activity of red yeast rice (RYR), its anticancer activities have been frequently reported. However, the mechanism of action of the anticancer activity of RYR is not yet fully understood. The objective of the current study was to elucidate anticancer compositions and anticancer mechanism of actions of RYR. The isolated compounds from RYR were subjected to anti-proliferation assay, apoptosis assay via flow cytometry, and telomerase inhibitory assay via telomeric repeat amplification protocol-PCR (TRAP-PCR) assay, and Western blotting assay in an in vitro cell culture system. The results showed that a statin, monacolin L, and a red pigment, rubropunctatin, from RYR exhibited very strong cancer cell proliferation inhibitory effects; the rubropunctatin was comparable with anticancer drug cis-platinum, taxol, and 10-hydroxy-camptothecin (HCPT) in their IC values. Monacolin L and rubropunctatin exerted their anticancer activity via telomerase inhibitory effects. Monacolin L and rubropunctatin presented the similar telomerase inhibitory effects as the anticancer drug cis-platinum, while the anticancer drug HCPT presented a weak telomerase inhibitory effect in the TRAP-PCR assay. Meanwhile, rubropunctatin and cis-platinum did not present strong apoptosis induction activity as the momacolin L and HCPT did. These results indicate that the RYR may exert anticancer effects through the telomerase inhibitory effect of rubropunctatin and the apoptosis-induction effect of monacolin L. |
关键词 | Anticancer Apoptosis Pigments Red yeast rice Telomerase |
DOI | 10.3390/genes8050129 |
URL | 查看来源 |
收录类别 | SCIE |
语种 | 英语English |
WOS研究方向 | Genetics & Heredity |
WOS类目 | Genetics & Heredity |
WOS记录号 | WOS:000404456100002 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://repository.uic.edu.cn/handle/39GCC9TT/1382 |
专题 | 理工科技学院 |
通讯作者 | Xu, Baojun |
作者单位 | 1.Beijing Normal University-Hong Kong Baptist University United International College,Zhuhai,519085,China 2.College of Food and Bioengineering,South China University of Technology,Guangzhou,510640,China 3.Department of Food Science and Technology,Chungnam National University,Taejon,305-764,South Korea |
第一作者单位 | 北师香港浸会大学 |
通讯作者单位 | 北师香港浸会大学 |
推荐引用方式 GB/T 7714 | Xu, Baojun,Wang, Qijun,Sung, Changkeun. Telomerase inhibitory effects of red pigment rubropunctatin and statin monacolin l isolated from red yeast rice[J]. Genes, 2017, 8(5). |
APA | Xu, Baojun, Wang, Qijun, & Sung, Changkeun. (2017). Telomerase inhibitory effects of red pigment rubropunctatin and statin monacolin l isolated from red yeast rice. Genes, 8(5). |
MLA | Xu, Baojun,et al."Telomerase inhibitory effects of red pigment rubropunctatin and statin monacolin l isolated from red yeast rice". Genes 8.5(2017). |
条目包含的文件 | 下载所有文件 | |||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
Xu-2017-Telomerase i(11468KB) | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论