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题名Telomerase inhibitory effects of red pigment rubropunctatin and statin monacolin l isolated from red yeast rice
作者
发表日期2017-05-01
发表期刊Genes
ISSN/eISSN2073-4425
卷号8期号:5
摘要

In addition to the cholesterol-lowering activity of red yeast rice (RYR), its anticancer activities have been frequently reported. However, the mechanism of action of the anticancer activity of RYR is not yet fully understood. The objective of the current study was to elucidate anticancer compositions and anticancer mechanism of actions of RYR. The isolated compounds from RYR were subjected to anti-proliferation assay, apoptosis assay via flow cytometry, and telomerase inhibitory assay via telomeric repeat amplification protocol-PCR (TRAP-PCR) assay, and Western blotting assay in an in vitro cell culture system. The results showed that a statin, monacolin L, and a red pigment, rubropunctatin, from RYR exhibited very strong cancer cell proliferation inhibitory effects; the rubropunctatin was comparable with anticancer drug cis-platinum, taxol, and 10-hydroxy-camptothecin (HCPT) in their IC values. Monacolin L and rubropunctatin exerted their anticancer activity via telomerase inhibitory effects. Monacolin L and rubropunctatin presented the similar telomerase inhibitory effects as the anticancer drug cis-platinum, while the anticancer drug HCPT presented a weak telomerase inhibitory effect in the TRAP-PCR assay. Meanwhile, rubropunctatin and cis-platinum did not present strong apoptosis induction activity as the momacolin L and HCPT did. These results indicate that the RYR may exert anticancer effects through the telomerase inhibitory effect of rubropunctatin and the apoptosis-induction effect of monacolin L.

关键词Anticancer Apoptosis Pigments Red yeast rice Telomerase
DOI10.3390/genes8050129
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收录类别SCIE
语种英语English
WOS研究方向Genetics & Heredity
WOS类目Genetics & Heredity
WOS记录号WOS:000404456100002
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符https://repository.uic.edu.cn/handle/39GCC9TT/1382
专题理工科技学院
通讯作者Xu, Baojun
作者单位
1.Beijing Normal University-Hong Kong Baptist University United International College,Zhuhai,519085,China
2.College of Food and Bioengineering,South China University of Technology,Guangzhou,510640,China
3.Department of Food Science and Technology,Chungnam National University,Taejon,305-764,South Korea
第一作者单位北师香港浸会大学
通讯作者单位北师香港浸会大学
推荐引用方式
GB/T 7714
Xu, Baojun,Wang, Qijun,Sung, Changkeun. Telomerase inhibitory effects of red pigment rubropunctatin and statin monacolin l isolated from red yeast rice[J]. Genes, 2017, 8(5).
APA Xu, Baojun, Wang, Qijun, & Sung, Changkeun. (2017). Telomerase inhibitory effects of red pigment rubropunctatin and statin monacolin l isolated from red yeast rice. Genes, 8(5).
MLA Xu, Baojun,et al."Telomerase inhibitory effects of red pigment rubropunctatin and statin monacolin l isolated from red yeast rice". Genes 8.5(2017).
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