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题名A tridomain model for potassium clearance in optic nerve of Necturus
作者
发表日期2021
发表期刊Biophysical Journal
ISSN/eISSN0006-3495 ; 1542-0086
卷号120期号:15页码:3008-3027
摘要

Complex fluids flow in complex ways in complex structures. Transport of water and various organic and inorganic molecules in the central nervous system are important in a wide range of biological and medical processes. However, the exact driving mechanisms are often not known. In this work, we investigate flows induced by action potentials in an optic nerve as a prototype of the central nervous system. Different from traditional fluid dynamics problems, flows in biological tissues such as the central nervous system are coupled with ion transport. They are driven by osmosis created by concentration gradient of ionic solutions, which in turn influence the transport of ions. Our mathematical model is based on the known structural and biophysical properties of the experimental system used by the Harvard group Orkand et al. Asymptotic analysis and numerical computation show the significant role of water in convective ion transport. The full model (including water) and the electrodiffusion model (excluding water) are compared in detail to reveal an interesting interplay between water and ion transport. In the full model, convection due to water flow dominates inside the glial domain. This water flow in the glia contributes significantly to the spatial buffering of potassium in the extracellular space. Convection in the extracellular domain does not contribute significantly to spatial buffering. Electrodiffusion is the dominant mechanism for flows confined to the extracellular domain. © 2021 Biophysical Society

DOI10.1016/j.bpj.2021.06.020
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收录类别SCIE
语种英语English
WOS研究方向Biophysics
WOS类目Biophysics
WOS记录号WOS:000681715400006
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符https://repository.uic.edu.cn/handle/39GCC9TT/5178
专题理工科技学院
作者单位
1.Department of Mathematics and Statistics, York University, Toronto, Ontario, Canada
2.Zu Chongzhi Center for Mathematics and Computational Sciences, Division of Natural and Applied Sciences, Duke Kunshan University, Kunshan, China
3.Department of Applied Mathematics, Illinois Institute of Technology, Chicago, IL, United States
4.Department of Physiology & Biophysics, Rush University, Chicago, IL, United States
5.Research Centre for Mathematics, Advanced Institute of Natural Sciences, Beijing Normal University (Zhuhai), Zhuhai, China
6.Division of Science and Technology, BNU-HKBU United International College, Zhuhai, China
推荐引用方式
GB/T 7714
Zhu, Yi,Xu, Shixin,Eisenberg, Robert S.et al. A tridomain model for potassium clearance in optic nerve of Necturus[J]. Biophysical Journal, 2021, 120(15): 3008-3027.
APA Zhu, Yi, Xu, Shixin, Eisenberg, Robert S., & Huang, Huaxiong. (2021). A tridomain model for potassium clearance in optic nerve of Necturus. Biophysical Journal, 120(15), 3008-3027.
MLA Zhu, Yi,et al."A tridomain model for potassium clearance in optic nerve of Necturus". Biophysical Journal 120.15(2021): 3008-3027.
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