发表状态 | 已发表Published |
题名 | Lipid metabolism disorders associated with dioxin exposure in a cohort of Chinese male workers revealed by a comprehensive lipidomics study |
作者 | |
发表日期 | 2021-10-01 |
发表期刊 | Environment International
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ISSN/eISSN | 0160-4120 |
卷号 | 155 |
摘要 | Dioxins, environmentally stable and ubiquitous, have been found to induce metabolic changes especially in lipids and be related to multiple diseases. However, limited study is available on lipid alternations related to human exposure to dioxins. This study aims to explore the serum lipidomic characterization and to understand the underlying mechanisms of adverse health risks associated with dioxin exposure. A lipidomic study integrating nontargeted lipidomics, and targeted free fatty acid (FFA) and acyl-coenzyme A (acyl-CoA) analyses were conducted to investigate the 94 serum samples from two groups of male workers with remarkably different dioxin concentrations. The obtained results exhibited distinct lipidomic signatures between the high and low exposed groups. A total of 37 lipids were identified with the significant changes. The results revealed that dioxin exposure caused accumulations of triglyceride (TG), ceramide (Cer) and sphingoid (So), remodeling of glycerophospholipid (GP), imbalanced FFA metabolism, as well as upregulation of platelet-activating factor (PAF). These findings implied the associations between dioxin exposure and potential adverse health risks including inflammation, apoptosis, cardiovascular diseases (CVDs), and liver diseases. This study is the first to explain the associations between dioxin exposure and health effects at the level of lipid metabolism. |
关键词 | Dioxins Lipid profiles Male workers Serum |
DOI | 10.1016/j.envint.2021.106665 |
URL | 查看来源 |
收录类别 | SCIE |
语种 | 英语English |
WOS研究方向 | Environmental Sciences & Ecology |
WOS类目 | Environmental Sciences |
WOS记录号 | WOS:000704393400004 |
Scopus入藏号 | 2-s2.0-85108104421 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://repository.uic.edu.cn/handle/39GCC9TT/5958 |
专题 | 理工科技学院 |
通讯作者 | Zhang, Jianqing |
作者单位 | 1.Beijing Normal University-Hong Kong Baptist University United International College, Zhuhai, China 2.State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong, China 3.Shenzhen Center for Disease Control and Prevention, Shenzhen, 518055, China 4.Department of Environmental and Occupational Health, School of Public Health, Guangdong Medical University, Dongguan, China 5.Songgang Preventive Health Center of Baoan District, Shenzhen, 518105, China |
第一作者单位 | 北师香港浸会大学 |
推荐引用方式 GB/T 7714 | Liang, Yanshan,Tang, Zhi,Jiang, Youshenget al. Lipid metabolism disorders associated with dioxin exposure in a cohort of Chinese male workers revealed by a comprehensive lipidomics study[J]. Environment International, 2021, 155. |
APA | Liang, Yanshan., Tang, Zhi., Jiang, Yousheng., Ai, Chunyan., Peng, Jinling., .. & Cai, Zongwei. (2021). Lipid metabolism disorders associated with dioxin exposure in a cohort of Chinese male workers revealed by a comprehensive lipidomics study. Environment International, 155. |
MLA | Liang, Yanshan,et al."Lipid metabolism disorders associated with dioxin exposure in a cohort of Chinese male workers revealed by a comprehensive lipidomics study". Environment International 155(2021). |
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