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题名Lipid metabolism disorders associated with dioxin exposure in a cohort of Chinese male workers revealed by a comprehensive lipidomics study
作者
发表日期2021-10-01
发表期刊Environment International
ISSN/eISSN0160-4120
卷号155
摘要

Dioxins, environmentally stable and ubiquitous, have been found to induce metabolic changes especially in lipids and be related to multiple diseases. However, limited study is available on lipid alternations related to human exposure to dioxins. This study aims to explore the serum lipidomic characterization and to understand the underlying mechanisms of adverse health risks associated with dioxin exposure. A lipidomic study integrating nontargeted lipidomics, and targeted free fatty acid (FFA) and acyl-coenzyme A (acyl-CoA) analyses were conducted to investigate the 94 serum samples from two groups of male workers with remarkably different dioxin concentrations. The obtained results exhibited distinct lipidomic signatures between the high and low exposed groups. A total of 37 lipids were identified with the significant changes. The results revealed that dioxin exposure caused accumulations of triglyceride (TG), ceramide (Cer) and sphingoid (So), remodeling of glycerophospholipid (GP), imbalanced FFA metabolism, as well as upregulation of platelet-activating factor (PAF). These findings implied the associations between dioxin exposure and potential adverse health risks including inflammation, apoptosis, cardiovascular diseases (CVDs), and liver diseases. This study is the first to explain the associations between dioxin exposure and health effects at the level of lipid metabolism.

关键词Dioxins Lipid profiles Male workers Serum
DOI10.1016/j.envint.2021.106665
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收录类别SCIE
语种英语English
WOS研究方向Environmental Sciences & Ecology
WOS类目Environmental Sciences
WOS记录号WOS:000704393400004
Scopus入藏号2-s2.0-85108104421
引用统计
被引频次:27[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符https://repository.uic.edu.cn/handle/39GCC9TT/5958
专题理工科技学院
通讯作者Zhang, Jianqing
作者单位
1.Beijing Normal University-Hong Kong Baptist University United International College, Zhuhai, China
2.State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong, China
3.Shenzhen Center for Disease Control and Prevention, Shenzhen, 518055, China
4.Department of Environmental and Occupational Health, School of Public Health, Guangdong Medical University, Dongguan, China
5.Songgang Preventive Health Center of Baoan District, Shenzhen, 518105, China
第一作者单位北师香港浸会大学
推荐引用方式
GB/T 7714
Liang, Yanshan,Tang, Zhi,Jiang, Youshenget al. Lipid metabolism disorders associated with dioxin exposure in a cohort of Chinese male workers revealed by a comprehensive lipidomics study[J]. Environment International, 2021, 155.
APA Liang, Yanshan., Tang, Zhi., Jiang, Yousheng., Ai, Chunyan., Peng, Jinling., .. & Cai, Zongwei. (2021). Lipid metabolism disorders associated with dioxin exposure in a cohort of Chinese male workers revealed by a comprehensive lipidomics study. Environment International, 155.
MLA Liang, Yanshan,et al."Lipid metabolism disorders associated with dioxin exposure in a cohort of Chinese male workers revealed by a comprehensive lipidomics study". Environment International 155(2021).
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