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题名Seizure Characteristics, Outcome, and Risk of Epilepsy in Pediatric Anti-N-Methyl-D-Aspartate Receptor Encephalitis
作者
发表日期2020-04-01
发表期刊Pediatric Neurology
ISSN/eISSN0887-8994
卷号105页码:35-40
摘要

Background: We identified seizure characteristics, long-term outcome, and predictors of persistent seizures in children with anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis. Method: Data were analyzed from patients with anti-NMDAR encephalitis who presented with seizures at our center between August 2012 and June 2018. Results: Sixty-two of 86 patients with anti-NMDAR encephalitis experienced seizures. Seizures occurred within two weeks of disease onset in 58 of 62 (93.6%) patients; 36 of 62 (58.1%) had seizures as the initial symptom. Males were more likely to exhibit seizures as the initial symptom (P = 0.039). More than a quarter of patients (17 of 62, 27.4%) manifested two or more seizure types. Focal seizures were the most common (46 of 62, 74.2%). Status epilepticus occurred in 27 of 62 (43.5%) patients, and nonconvulsive status epilepticus, in two of 62 (3.2%) patients. No patient developed refractory status epilepticus. No systemic tumors were found. Electroencephalographic abnormalities included background slowing (77.4%), absence of a posterior dominant rhythm (62.9%), interictal epileptic discharges (50.0%), and extreme delta brush (6.5%). In the acute phase, 45 patients (45 of 62, 72.6%) received antiepileptic drugs. Persistent seizures occurred in only five of 62 (8%) patients. On univariate analysis, status epilepticus and combination antiepileptic drug treatment were associated with persistent seizures, but neither independently predicted persistent seizures. Conclusions: Multiple seizure types may develop at any stage of anti-N-methyl-D-aspartate receptor encephalitis. Refractory status epilepticus, systemic tumors, and extreme delta brush in electroencephalography are rare in pediatric patients. Anti-NMDAR encephalitis–associated seizures appear to have good prognosis, without the need for long-term antiepileptic drug treatment.

关键词Anti-NMDAR encephalitis Autoimmune encephalitis EEG Pediatrics Seizures Status epilepticus
DOI10.1016/j.pediatrneurol.2019.11.011
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收录类别SCIE
语种英语English
WOS研究方向Neurosciences & Neurology ; Pediatrics
WOS类目Clinical Neurology ; Pediatrics
WOS记录号WOS:000520947400006
Scopus入藏号2-s2.0-85077357809
引用统计
被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符https://repository.uic.edu.cn/handle/39GCC9TT/6181
专题理工科技学院
通讯作者Hu, Yue
作者单位
1.Department of Neurology,Children's Hospital of Chongqing Medical University,Chongqing,China
2.Ministry of Education Key Laboratory of Child Development and Disorders,Chongqing,China
3.National Clinical Research Center for Child Health and Disorders,Chongqing,China
4.China International Science and Technology Cooperation Base of Child Development and Critical Disorders,Chongqing,China
5.Chongqing Key Laboratory of Pediatrics,Chongqing,China
6.Division of Pediatric Neurology,Department of Pediatrics,The Ohio State University,Nationwide Children's Hospital,Chongqing,China
7.Division of Science and Technology,Beijing Normal University-Hongkong Baptist Univesity United International College,Zhuhai,China
推荐引用方式
GB/T 7714
Qu, Xinping,Vidaurre, Jorge,Peng, Xiaolinget al. Seizure Characteristics, Outcome, and Risk of Epilepsy in Pediatric Anti-N-Methyl-D-Aspartate Receptor Encephalitis[J]. Pediatric Neurology, 2020, 105: 35-40.
APA Qu, Xinping, Vidaurre, Jorge, Peng, Xiaoling, Jiang, Li, Zhong, Min, & Hu, Yue. (2020). Seizure Characteristics, Outcome, and Risk of Epilepsy in Pediatric Anti-N-Methyl-D-Aspartate Receptor Encephalitis. Pediatric Neurology, 105, 35-40.
MLA Qu, Xinping,et al."Seizure Characteristics, Outcome, and Risk of Epilepsy in Pediatric Anti-N-Methyl-D-Aspartate Receptor Encephalitis". Pediatric Neurology 105(2020): 35-40.
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