题名 | Multiple Mechanisms are Involved in Salt-Sensitive Hypertension-Induced Renal Injury and Interstitial Fibrosis |
作者 | |
发表日期 | 2017-04-06 |
发表期刊 | Scientific Reports
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卷号 | 7 |
摘要 | Salt-sensitive hypertension (SSHT) leads to kidney interstitial fibrosis. However, the potential mechanisms leading to renal fibrosis have not been well investigated. In present study, Dahl salt-sensitive (DS) rats were divided into three groups: normal salt diet (DSN), high salt diet (DSH) and high salt diet treated with hydrochlorothiazide (HCTZ) (DSH + HCTZ). A significant increase in systolic blood pressure (SBP) was observed 3 weeks after initiating the high salt diet, and marked histological alterations were observed in DSH rats. DSH rats showed obvious podocyte injury, peritubular capillary (PTC) loss, macrophage infiltration, and changes in apoptosis and cell proliferation. Moreover, Wnt/β-catenin signaling was significantly activated in DSH rats. However, HCTZ administration attenuated these changes with decreased SBP. In addition, increased renal and urinary Wnt4 expression was detected with time in DSH rats and was closely correlated with histopathological alterations. Furthermore, these alterations were also confirmed by clinical study. In conclusion, the present study provides novel insight into the mechanisms related to PTC loss, macrophage infiltration and Wnt/β-catenin signaling in SSHT-induced renal injury and fibrosis. Therefore, multi-target therapeutic strategies may be the most effective in preventing these pathological processes. Moreover, urinary Wnt4 may be a noninvasive biomarker for monitoring renal injury after hypertension. |
DOI | 10.1038/srep45952 |
URL | 查看来源 |
语种 | 英语English |
Scopus入藏号 | 2-s2.0-85017112121 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://repository.uic.edu.cn/handle/39GCC9TT/6363 |
专题 | 北师香港浸会大学 |
通讯作者 | Li,Bing |
作者单位 | 1.Department of Nephrology,Second Affiliated Hospital of Harbin,Medical University,Harbin,China 2.Financial Mathematics,Beijing Normal University-Hong Kong,Baptist University United International College,Zhuhai,China |
推荐引用方式 GB/T 7714 | Wei,Shi Yao,Wang,Yu Xiao,Zhang,Qing Fanget al. Multiple Mechanisms are Involved in Salt-Sensitive Hypertension-Induced Renal Injury and Interstitial Fibrosis[J]. Scientific Reports, 2017, 7. |
APA | Wei,Shi Yao., Wang,Yu Xiao., Zhang,Qing Fang., Zhao,Shi Lei., Diao,Tian Tian., .. & Li,Bing. (2017). Multiple Mechanisms are Involved in Salt-Sensitive Hypertension-Induced Renal Injury and Interstitial Fibrosis. Scientific Reports, 7. |
MLA | Wei,Shi Yao,et al."Multiple Mechanisms are Involved in Salt-Sensitive Hypertension-Induced Renal Injury and Interstitial Fibrosis". Scientific Reports 7(2017). |
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