The RhoA GTPase-activating protein DLC2 modulates RhoA activity and hyperalgesia to noxious thermal and inflammatory stimuli

doi:10.1159/000331240

科研成果详情

题名	The RhoA GTPase-activating protein DLC2 modulates RhoA activity and hyperalgesia to noxious thermal and inflammatory stimuli
作者	Chan，Fred K.C.1; Chung，Stephen S.M.1,4; Ng，Irene O.3; Chung，Sookja K.1,2
发表日期	2012
发表期刊	NeuroSignals
ISSN/eISSN	1424-862X
卷号	20 期号:2 页码:112-126
摘要	Deleted in liver cancer 2 (DLC2) is a novel Rho GTPase-activating protein that regulates RhoA activity. DLC2 is ubiquitously expressed in most tissues, including the brain, spinal cord and peripheral nerves, and is thought to be involved in actin cytoskeletal reorganization. Unlike DLC1-deficient mice, DLC2-deficient mice (DLC2 ) are viable and without gross anatomical abnormalities. Interestingly, DLC2 mice exhibit hyperalgesia to noxious thermal stimuli and inflammation-inducing chemicals, such as formalin and acetic acid. There was no difference in the structure or morphology of cutaneous or sural nerves between DLC2 and DLC2 mice. However, sensory nerve conduction velocity in DLC2 mice was significantly higher than that in DLC2 mice, whereas motor nerve conduction velocity was not affected. After formalin injection, DLC2 mice showed increased RhoA activity in the spinal cord and an increased number of phosphorylated ERK1/2-positive cells. The inflammatory hyperalgesia in DLC2 mice appeared to be mediated through the activation of RhoA and ERK1/2. Taken together, DLC2 plays a key role in pain modulation during inflammation by suppressing the activation of RhoA and ERK to prevent an exaggerated pain response, and DLC2 mice provide a valuable tool for further understanding the regulation of inflammatory pain. Copyright © 2011 S. Karger AG, Basel.
关键词	Deleted in liver cancer 2 ERK Hyperalgesia Inflammation Nerve conduction velocity Pain RhoA
DOI	10.1159/000331240
URL	查看来源
语种	英语English
Scopus入藏号	2-s2.0-84858998423
引用统计	被引频次：10[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://repository.uic.edu.cn/handle/39GCC9TT/6588
专题	北师香港浸会大学
作者单位	1.Department of Anatomy,Li Ka Shing Faculty of Medicine,University of Hong Kong,21 Sassoon Road,Hong Kong,Hong Kong 2.Research Center of Heart, Brain, Hormone and Healthy Aging,Li Ka Shing Faculty of Medicine,University of Hong Kong,Hong Kong,Hong Kong 3.Department of Pathology,Li Ka Shing Faculty of Medicine,University of Hong Kong,Hong Kong,Hong Kong 4.Division of Science and Technology,United International College,Zhuhai,China
推荐引用方式 GB/T 7714	Chan，Fred K.C.,Chung，Stephen S.M.,Ng，Irene O.et al. The RhoA GTPase-activating protein DLC2 modulates RhoA activity and hyperalgesia to noxious thermal and inflammatory stimuli[J]. NeuroSignals, 2012, 20(2): 112-126.
APA	Chan，Fred K.C., Chung，Stephen S.M., Ng，Irene O., & Chung，Sookja K. (2012). The RhoA GTPase-activating protein DLC2 modulates RhoA activity and hyperalgesia to noxious thermal and inflammatory stimuli. NeuroSignals, 20(2), 112-126.
MLA	Chan，Fred K.C.,et al."The RhoA GTPase-activating protein DLC2 modulates RhoA activity and hyperalgesia to noxious thermal and inflammatory stimuli". NeuroSignals 20.2(2012): 112-126.