Effects and mechanism of turmeric vasorelaxation of the thoracic aorta in hypercholesterolemic rats

doi:10.1089/jmf.2011.1625

科研成果详情

题名	Effects and mechanism of turmeric vasorelaxation of the thoracic aorta in hypercholesterolemic rats
作者	Kam，Tsz Shan 1; Wong，Cho Yee 1; Kwan，Pui Long 1; Wing，Fat Yiu 1; Chiu，Sin Ming 1; Chan，Shun Wan 1; Yuen，Kit San 1; Chan，Robbie 1,2
发表日期	2012-02-01
发表期刊	Journal of Medicinal Food
ISSN/eISSN	1096-620X
卷号	15 期号:2 页码:190-199
摘要	An extract of Curcuma longa was tested in hypercholesterolemic rats to investigate its potential therapeutic effect on vascular conditions. Four experimental groups were used: normal diet (ND) control group, high cholesterol diet (HCD) group, and HCD subgroups supplemented with turmeric extract at 100 or 300 mg/kg of body weight (HCD100Tur and HCD300Tur groups, respectively). Turmeric extract was fed orally to animals, and dietary treatments lasted for 28 days. Hypercholesterolemia developed in the HCD, HCD100Tur, and HCD300Tur rats. Segments of the thoracic aorta were isolated, and an organ bath experiment was used to assess the vasorelaxation capability among all rats. Rats fed only HCD showed a marked decrease in acetylcholine-induced vasorelaxation compared with ND control rats. The HCD100Tur and HCD300Tur rats showed significant improvement in vasorelaxation compared with HCD rats. When vasorelaxation was induced by high concentrations of sodium nitroprusside, no differences in vasorelaxation were observed among the four groups of rats. A mechanistic study showed that HCD100Tur and HCD300Tur rats had significantly higher levels of the antioxidant enzymes superoxide dismutase and glutathione peroxidase than HCD rats. The transcript levels of heat shock protein 70 (hsp70), bcl2, bax-α, caspase (casp3), and glyceraldehyde 3-phosphate dehydrogenase in aortic tissues indicated that hypercholesterolemia significantly increased the expression of bax-α and casp3 but down-regulated bcl2 expression compared with the control group. Turmeric increased the expression of hsp70 and bcl2 but greatly reduced casp3 expression, indicating that turmeric improves vasorelaxation of the aorta in hypercholesterolemic rats by increasing antioxidant enzyme activities and likely suppressing apoptosis. © 2012, Mary Ann Liebert, Inc. and Korean Society of Food Science and Nutrition.
关键词	apoptosis atherosclerosis index hypercholesterolemia turmeric vasorelaxation
DOI	10.1089/jmf.2011.1625
URL	查看来源
语种	英语English
Scopus入藏号	2-s2.0-84863398683
引用统计	被引频次：8[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://repository.uic.edu.cn/handle/39GCC9TT/6590
专题	北师香港浸会大学
通讯作者	Chan，Robbie
作者单位	1.Department of Applied Biology and Chemical Technology,Hong Kong Polytechnic University,Kowloon,Hong Kong 2.Program of Food Science and Technology,BNU-HKBU United International College,Zhuhai,China
通讯作者单位	北师香港浸会大学
推荐引用方式 GB/T 7714	Kam，Tsz Shan,Wong，Cho Yee,Kwan，Pui Longet al. Effects and mechanism of turmeric vasorelaxation of the thoracic aorta in hypercholesterolemic rats[J]. Journal of Medicinal Food, 2012, 15(2): 190-199.
APA	Kam，Tsz Shan., Wong，Cho Yee., Kwan，Pui Long., Wing，Fat Yiu., Chiu，Sin Ming., .. & Chan，Robbie. (2012). Effects and mechanism of turmeric vasorelaxation of the thoracic aorta in hypercholesterolemic rats. Journal of Medicinal Food, 15(2), 190-199.
MLA	Kam，Tsz Shan,et al."Effects and mechanism of turmeric vasorelaxation of the thoracic aorta in hypercholesterolemic rats". Journal of Medicinal Food 15.2(2012): 190-199.