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题名Efficacy and safety of intravenous high-dose immunoglobulin in treatment of the severe form of Japanese encephalitis
作者
发表日期2022
发表期刊Neurological Sciences
ISSN/eISSN1590-1874
卷号43期号:6页码:3911-3918
摘要

Purpose: To explore the efficacy and safety of intravenous immunoglobulin (IVIG) in the treatment of severe Japanese encephalitis (JE). Methods: A retrospective study of 124 children diagnosed with the severe or very severe form of JE was undertaken. There were 62 cases in the IVIG group and control group. The efficacy, safety, and tolerability of IVIG were evaluated 3 days, as well as 1, 2, and 3 weeks after IVIG, respectively, and the prognosis was assessed at 6 months. Results: Cox regression survival analysis suggested that the IVIG group reached the criteria for efficacious treatment faster than that in the control group. The duration of unconsciousness and the number of days of seizures, a dull response to light, the pyramidal sign, and meningeal-irritation sign in the IVIG group were shorter than those in the control group (p < 0.05). The number of complications occurring in the IVIG group (including gastrointestinal bleeding and pneumonia) was less than that in the control group (p < 0.05). Cox regression survival analysis suggested that age (p = 0.003) and imaging abnormalities (p = 0.042) had an effect on the efficacy of IVIG treatment. The Liverpool Outcome Score at 6 months showed that the prognosis of the IVIG group was better than that of the control group (p < 0.05). IVIG treatment was safe and tolerable. Conclusion: IVIG showed good efficacy, safety, and tolerance for treatment of the severe form of JE. The age and imaging abnormalities of patients affect the efficacy of IVIG treatment.

关键词Efficacy Immunoglobulin Japanese encephalitis Safety
DOI10.1007/s10072-022-05891-6
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收录类别SCIE
语种英语English
WOS研究方向Neurosciences & Neurology
WOS类目Clinical Neurology ; Neurosciences
WOS记录号WOS:000744403500002
Scopus入藏号2-s2.0-85123065854
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符https://repository.uic.edu.cn/handle/39GCC9TT/8274
专题理工科技学院
通讯作者Hu, Yue
作者单位
1.Department of Neurology,Children’s Hospital of Chongqing Medical University,Chongqing,No.136 Zhongshan 2nd Road, Yu Zhong District,400014,China
2.Ministry of Education Key Laboratory of Child Development and Disorders,Chongqing,China
3.National Clinical Research Center for Child Health and Disorders,Chongqing,China
4.China International Science and Technology Cooperation Base of Child Development and Critical Disorders,Chongqing,China
5.Chongqing Key Laboratory of Pediatrics,Chongqing,China
6.Guangzhou Women and Children’s Medical Center,Guangzhou,China
7.Division of Science and Technology,Beijing Normal University-Hongkong Baptist University United International College,Beijing,China
8.Department of Pediatrics,Sichuan Provincial People’s Hospital,Chengdu,China
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GB/T 7714
Chen, Dan,Peng, Xiaoling,Zhan, Yuet al. Efficacy and safety of intravenous high-dose immunoglobulin in treatment of the severe form of Japanese encephalitis[J]. Neurological Sciences, 2022, 43(6): 3911-3918.
APA Chen, Dan, Peng, Xiaoling, Zhan, Yu, Wu, Peng, Jiang, Li, & Hu, Yue. (2022). Efficacy and safety of intravenous high-dose immunoglobulin in treatment of the severe form of Japanese encephalitis. Neurological Sciences, 43(6), 3911-3918.
MLA Chen, Dan,et al."Efficacy and safety of intravenous high-dose immunoglobulin in treatment of the severe form of Japanese encephalitis". Neurological Sciences 43.6(2022): 3911-3918.
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