发表状态 | 已发表Published |
题名 | Black Truffle Extract Exerts Antidiabetic Effects through Inhibition of Inflammation and Lipid Metabolism Regulation |
作者 | |
发表日期 | 2022 |
发表期刊 | Oxidative Medicine and Cellular Longevity
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ISSN/eISSN | 1942-0900 |
卷号 | 2022 |
摘要 | Black truffle, a culinary and medical fungus, is highly valued worldwide for its nutritional and therapeutic importance. To enhance the existing knowledge about the beneficial properties, this study investigates the antioxidant, antihyperlipidemic, and anti-inflammatory effects of black truffle extract in in vitro biochemical assays and animal study. Briefly, black truffle extract was administered orally to treat streptozotocin- (STZ-) induced diabetic Wistar rats for 45 days. At the end of the experimental duration, rats were sacrificed to perform biochemical and gene expression analyses related to lipid regulatory and inflammatory pathways. Our results indicated that total cholesterol, triglycerides, free fatty acids, phospholipids, and low-density lipoprotein in different tissues and circulation were significantly increased in diabetic rats. Furthermore, the β-hydroxy β-methylglutaryl-CoA enzyme was also significantly increased; lipoprotein lipase and lecithin-cholesterol acyltransferase enzymes were significantly decreased in diabetic rats. However, the above conditions were reversed upon black truffle extract feeding. Furthermore, black truffle extract was also found to downregulate the expression of proinflammatory cytokines (tumor necrosis factor-α and interleukin-6) and lipid regulatory genes (serum regulatory element-binding protein-1 and fatty acid synthase). The truffle extract-treated effects were comparable to glibenclamide and medication commonly used to treat diabetes mellitus. Overall, our results suggested that black truffle possesses strong antihyperlipidemic and anti-inflammatory effects on diabetic rats. These findings will enhance the current knowledge about the therapeutic importance of black truffles. They might be exploited as a possible food supplement or even as a natural source of pharmaceutical agents for diabetes prevention and treatment. |
DOI | 10.1155/2022/6099872 |
URL | 查看来源 |
收录类别 | SCIE |
语种 | 英语English |
WOS研究方向 | Cell Biology |
WOS类目 | Cell Biology |
WOS记录号 | WOS:000777832300005 |
Scopus入藏号 | 2-s2.0-85125796803 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://repository.uic.edu.cn/handle/39GCC9TT/8942 |
专题 | 理工科技学院 |
通讯作者 | Xu, Baojun |
作者单位 | 1.Food Science and Technology Program,BNU-HKBU United International College,Guangdong,Zhuhai,519087,China 2.Department of Endocrinology and Metabolism,Shanghai Tenth People's Hospital,School of Medicine,Tongji University,Shanghai,200072,China 3.Institute of Chinese Medical Sciences,State Key Laboratory of Quality Research in Chinese Medicine,University of Macau,Macao |
第一作者单位 | 北师香港浸会大学 |
通讯作者单位 | 北师香港浸会大学 |
推荐引用方式 GB/T 7714 | Wu, Ziyuan,Jayachandran, Muthukumaran,Cheang, Wai Sanet al. Black Truffle Extract Exerts Antidiabetic Effects through Inhibition of Inflammation and Lipid Metabolism Regulation[J]. Oxidative Medicine and Cellular Longevity, 2022, 2022. |
APA | Wu, Ziyuan, Jayachandran, Muthukumaran, Cheang, Wai San, & Xu, Baojun. (2022). Black Truffle Extract Exerts Antidiabetic Effects through Inhibition of Inflammation and Lipid Metabolism Regulation. Oxidative Medicine and Cellular Longevity, 2022. |
MLA | Wu, Ziyuan,et al."Black Truffle Extract Exerts Antidiabetic Effects through Inhibition of Inflammation and Lipid Metabolism Regulation". Oxidative Medicine and Cellular Longevity 2022(2022). |
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