Biological glucose metabolism regulated peptide self-assembly as a simple visual biosensor for glucose detection

doi:10.1002/marc.201100689

科研成果详情

发表状态	已发表Published
题名	Biological glucose metabolism regulated peptide self-assembly as a simple visual biosensor for glucose detection
作者	Xu, Xiaoding; Lin, Bingbing; Feng, Jun; Wang, Ya; Cheng, Sixue; Zhang, Xianzheng; Zhuo, Renxi
发表日期	2012-03-16
发表期刊	Macromolecular Rapid Communications
ISSN/eISSN	1022-1336
卷号	33 期号:5 页码:426-431
摘要	A glucose oxidase (GOx)-mediated glucose metabolism was in vitro mimicked and employed to regulate the self-assembly of peptide-based building blocks. In this new stimuli-responsive self-assembly system, two peptide-based building blocks, respectively, having aspartic acid (gelator 1) and lysine (gelator 2) residues were designed and prepared. When adding glucose and GOx to the aqueous solution of gelator 1 or the self-assembled fibrillar hydrogel of gelator 2 to construct glucose metabolism system, the metabolic product (gluconic acid) can trigger the protonation of the peptide molecules and induce the phase transitions of gelators 1 (sol-gel) and 2 (gel-sol). Because this glucose metabolism regulated peptide self-assembly is built on the oxidation of glucose, it can be used as a simple visual biosensor for glucose detection. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
关键词	glucose detection glucose metabolism peptide self-assembly
DOI	10.1002/marc.201100689
URL	查看来源
收录类别	SCIE
语种	英语English
WOS研究方向	Polymer Science
WOS类目	Polymer Science
WOS记录号	WOS:000301115600012
Scopus入藏号	2-s2.0-84863267174
引用统计	被引频次：65[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://repository.uic.edu.cn/handle/39GCC9TT/9111
专题	个人在本单位外知识产出
通讯作者	Zhang, Xianzheng
作者单位	Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry,Wuhan University,Wuhan 430072,China
推荐引用方式 GB/T 7714	Xu, Xiaoding,Lin, Bingbing,Feng, Junet al. Biological glucose metabolism regulated peptide self-assembly as a simple visual biosensor for glucose detection[J]. Macromolecular Rapid Communications, 2012, 33(5): 426-431.
APA	Xu, Xiaoding., Lin, Bingbing., Feng, Jun., Wang, Ya., Cheng, Sixue., .. & Zhuo, Renxi. (2012). Biological glucose metabolism regulated peptide self-assembly as a simple visual biosensor for glucose detection. Macromolecular Rapid Communications, 33(5), 426-431.
MLA	Xu, Xiaoding,et al."Biological glucose metabolism regulated peptide self-assembly as a simple visual biosensor for glucose detection". Macromolecular Rapid Communications 33.5(2012): 426-431.