A Comprehensive Analysis of Programmed Cell Death-Associated Genes for Tumor Microenvironment Evaluation Promotes Precise Immunotherapy in Patients with Lung Adenocarcinoma

doi:10.3390/jpm13030476

科研成果详情

题名	A Comprehensive Analysis of Programmed Cell Death-Associated Genes for Tumor Microenvironment Evaluation Promotes Precise Immunotherapy in Patients with Lung Adenocarcinoma
作者	Huang，Yunxi 1,2; Ouyang，Wenhao 1; Wang，Zehua 3; Huang，Hong 4; Ou，Qiyun 1,3; Lin，Ruichong 3; Yu，Yunfang 1,5; Yao，Herui 1
发表日期	2023-03-01
发表期刊	Journal of Personalized Medicine
卷号	13 期号:3
摘要	Immune checkpoint inhibitors (ICIs) represent a new hot spot in tumor therapy. Programmed cell death has an important role in the prognosis. We explore a programmed cell death gene prognostic model associated with survival and immunotherapy prediction via computational algorithms. Patient details were obtained from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus databases. We used LASSO algorithm and multiple-cox regression to establish a programmed cell death-associated gene prognostic model. Further, we explored whether this model could evaluate the sensitivity of patients to anti-PD-1/PD-L1. In total, 1342 patients were included. We constructed a programmed cell death model in TCGA cohorts, and the overall survival (OS) was significantly different between the high- and low-risk score groups (HR 2.70; 95% CI 1.94–3.75; p < 0.0001; 3-year OS AUC 0.71). Specifically, this model was associated with immunotherapy progression-free survival benefit in the validation cohort (HR 2.42; 95% CI 1.59–3.68; p = 0.015; 12-month AUC 0.87). We suggest that the programmed cell death model could provide guidance for immunotherapy in LUAD patients.
关键词	immunotherapy lung adenocarcinoma prognostic prediction programmed cell death tumor microenvironment
DOI	10.3390/jpm13030476
URL	查看来源
语种	英语English
Scopus入藏号	2-s2.0-85152675563
引用统计
文献类型	期刊论文
条目标识符	https://repository.uic.edu.cn/handle/39GCC9TT/11592
专题	北师香港浸会大学
通讯作者	Yu，Yunfang
作者单位	1.Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation,Department of Medical Oncology,Breast Tumor Center,Phase I Clinical Trial Center,Sun Yat-sen Memorial Hospital,Sun Yat-sen University,Guangzhou,510120,China 2.Department of Experimental Research,The Affiliated Tumor Hospital of Guangxi Medical University,Nanning,530000,China 3.Division of Science and Technology,Beijing Normal University-Hong Kong Baptist University United International College,Zhuhai,519000,China 4.School of Medicine,Guilin Medical University,Guilin,541000,China 5.Faculty of Medicine,Macau University of Science and Technology,Taipa,999078,Macao
推荐引用方式 GB/T 7714	Huang，Yunxi,Ouyang，Wenhao,Wang，Zehuaet al. A Comprehensive Analysis of Programmed Cell Death-Associated Genes for Tumor Microenvironment Evaluation Promotes Precise Immunotherapy in Patients with Lung Adenocarcinoma[J]. Journal of Personalized Medicine, 2023, 13(3).
APA	Huang，Yunxi., Ouyang，Wenhao., Wang，Zehua., Huang，Hong., Ou，Qiyun., .. & Yao，Herui. (2023). A Comprehensive Analysis of Programmed Cell Death-Associated Genes for Tumor Microenvironment Evaluation Promotes Precise Immunotherapy in Patients with Lung Adenocarcinoma. Journal of Personalized Medicine, 13(3).
MLA	Huang，Yunxi,et al."A Comprehensive Analysis of Programmed Cell Death-Associated Genes for Tumor Microenvironment Evaluation Promotes Precise Immunotherapy in Patients with Lung Adenocarcinoma". Journal of Personalized Medicine 13.3(2023).