| Title | 3,4′,5-Trimethoxy-trans-stilbene ameliorates hepatic insulin resistance and oxidative stress in diabetic obese mice through insulin and Nrf2 signaling pathways |
| Creator | |
| Date Issued | 2024-02-15 |
| Source Publication | Food and Function
 |
| ISSN | 2042-6496 |
| Volume | 15Issue:6Pages:2996-3007 |
| Abstract | Resveratrol has profound benefits against diabetes. However, whether its methylated derivative 3,4′,5-trimethoxy-trans-stilbene (3,4′,5-TMS) also plays a protective role in glucose metabolism is not characterized. We aimed to study the anti-diabetic effects of 3,4′,5-TMS in vitro and in vivo. Insulin-resistant HepG2 cells (IR-HepG2) were induced by high glucose plus dexamethasone whilst six-week-old male C57BL/6J mice received a 60 kcal% fat diet for 14 weeks to establish an obese diabetic model. 3,4′,5-TMS did not reduce the cell viability of IR-HepG2 cells at concentrations of 0.5 and 1 μM, which enhanced the capability of glycogen synthesis and glucose consumption in IR-HepG2 cells. Four-week oral administration of 3,4′,5-TMS at 10 mg kg day ameliorated insulin sensitivity and glucose tolerance of diet-induced obese (DIO) mice. 3,4′,5-TMS activated the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) pathway by inhibiting phosphorylation of insulin receptor substrate (IRS)-1 at Ser307 and increasing the protein levels of IRS-1 and IRS-2 to restore the insulin signaling pathway in diabetes. 3,4′,5-TMS also upregulated the phosphorylation of glycogen synthase kinase 3 beta (GSK3β) at Ser9. 3,4′,5-TMS suppressed oxidative stress by increasing the protein levels of nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1) and NAD(P)H : quinone oxidoreductase 1 (NQO1) and antioxidant enzyme activity. In summary, 3,4′,5-TMS alleviated hepatic insulin resistance in vitro and in vivo, by the activation of the insulin signaling pathway, accomplished by the suppression of oxidative stress. |
| DOI | 10.1039/d3fo04158a |
| URL | View source |
| Language | 英语English |
| Scopus ID | 2-s2.0-85186457750 |
| Citation statistics | |
| Document Type | Journal article |
| Identifier | http://repository.uic.edu.cn/handle/39GCC9TT/11633 |
| Collection | Beijing Normal-Hong Kong Baptist University |
| Corresponding Author | Xu，Baojun |
| Affiliation | 1.Institute of Chinese Medical Sciences,State Key Laboratory of Quality Research in Chinese Medicine,University of Macau,SAR,Macao 2.Department of Pharmacy,Abdul Wali Khan University Mardan,Mardan,23200,Pakistan 3.Food Science and Technology Program,BNU-HKBU United International College,Zhuhai,Guangdong,China |
| Corresponding Author Affilication | Beijing Normal-Hong Kong Baptist University |
| Recommended Citation GB/T 7714 | Tan，Yi,Zhou，Chunxiu,Miao，Lingchaoet al. 3,4′,5-Trimethoxy-trans-stilbene ameliorates hepatic insulin resistance and oxidative stress in diabetic obese mice through insulin and Nrf2 signaling pathways[J]. Food and Function, 2024, 15(6): 2996-3007. |
| APA | Tan，Yi., Zhou，Chunxiu., Miao，Lingchao., Zhang，Xutao., Khan，Haroon., .. & Cheang，Wai San. (2024). 3,4′,5-Trimethoxy-trans-stilbene ameliorates hepatic insulin resistance and oxidative stress in diabetic obese mice through insulin and Nrf2 signaling pathways. Food and Function, 15(6), 2996-3007. |
| MLA | Tan，Yi,et al."3,4′,5-Trimethoxy-trans-stilbene ameliorates hepatic insulin resistance and oxidative stress in diabetic obese mice through insulin and Nrf2 signaling pathways". Food and Function 15.6(2024): 2996-3007. |
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