| Title | Effects of dibutyryl camp and bacterial toxins on indoleamine-induced encystment of dinoflagellates |
| Creator | |
| Date Issued | 1996 |
| Source Publication | NeuroSignals
 |
| ISSN | 1424-862X |
| Volume | 5Issue:1Pages:22-29 |
| Abstract | Dinoflagellates are the causative agents of red tides with worldwide occurrence and can be induced to encyst by indoleamines such as melatonin and 5-methoxytryptamine (5-MOT). This biological response may be mediated via indoleamine-binding proteins or receptors. Here we report the initial characterization of the signal transduction mechanisms by which indoleamines induce encystment of dinoflagellates. In particular, we explored the possible involvement of G proteins and cAMP in cyst formation. Both melatonin and 5-MOT promoted the encystment of Gonyaulax tamarensis and Crypthecodinium cohnii. Exposure of dinoflagellates to dibutyryl cAMP, which directly activates cAMP-dependent pathways, did not affect the ability of indoleamines to promote encystment. However, dibutyryl cAMP dose-dependently diminished the indoleamine-induced suppression of cell growth. Exposure of dinoflagellates to the bacterial toxins from Vibrio cholerae and Bordetella pertussis had no effect on the indoleamine-induced encystment response, indicating the lack of involvement of G or G-like proteins. Moreover, [P]ADP ribosylation of dinoflagellate membranes by either toxin failed to identify substrate proteins. These results suggest that although the indoleamine-induced encystment of dinoflagellates may involve a G-protein-coupled signal transduction pathway, the identity of the G protein concerned may be distinct from those that regulate adenylyl cyclases in mammalian cells. © 1996 S. Karger AG, Basel. |
| Keyword | cAMP Dinoflagellate G proteins Melatonin Signal transduction |
| DOI | 10.1159/000109170 |
| URL | View source |
| Language | 英语English |
| Scopus ID | 2-s2.0-0029927873 |
| Citation statistics | |
| Document Type | Journal article |
| Identifier | http://repository.uic.edu.cn/handle/39GCC9TT/11709 |
| Collection | Research outside affiliated institution |
| Corresponding Author | Wong，Yung H. |
| Affiliation | Department of Biology,Hong Kong University of Science and Technology,Kowloon,Hong Kong |
| Recommended Citation GB/T 7714 | Tsim，Siu Tai,Wong，Joseph T.Y.,Wong，Yung H. Effects of dibutyryl camp and bacterial toxins on indoleamine-induced encystment of dinoflagellates[J]. NeuroSignals, 1996, 5(1): 22-29. |
| APA | Tsim，Siu Tai, Wong，Joseph T.Y., & Wong，Yung H. (1996). Effects of dibutyryl camp and bacterial toxins on indoleamine-induced encystment of dinoflagellates. NeuroSignals, 5(1), 22-29. |
| MLA | Tsim，Siu Tai,et al."Effects of dibutyryl camp and bacterial toxins on indoleamine-induced encystment of dinoflagellates". NeuroSignals 5.1(1996): 22-29. |
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