Stimulation of cAMP accumulation by the cloned Xenopus melatonin receptor through Gi and Gz proteins

doi:10.1016/0014-5793(95)00963-A

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Title	Stimulation of cAMP accumulation by the cloned Xenopus melatonin receptor through Gi and Gz proteins
Creator	Yung，Lisa Y.; Tsim，Siu Tai; Wong，Yung H.
Date Issued	1995-09-18
Source Publication	FEBS Letters
ISSN	0014-5793
Volume	372 Issue:1 Pages:99-102
Abstract	The Xenopus melatonin receptor was expressed in human embryonic kidney 293 cells and assayed for cAMP accumulation. In transfected 293 cells expressing the melatonin receptor, melatonin dose-dependently inhibited the endogenous adenylyl cyclases. In contrast, melatonin stimulated the accumulation of cAMP in cells co-expressing the type II adenylyl cyclase. Both the inhibitory and stimulatory responses to melatonin were mediated via G-like proteins as they were blocked by pertussis toxin. Upon co-transfection with the α subunit of G, the ability of melatonin to regulate both type II and the endogenous adenylyl cyclases became refractory to pertussis toxin, indicating that the melatonin receptor can also couple to G. However, other pertussis toxin-insensitive G proteins such as G, G and G were unable to interact with the melatonin receptor. © 1995.
Keyword	Adenylyl cyclase G protein Melatonin receptor Signal transduction
DOI	10.1016/0014-5793(95)00963-A
URL	View source
Language	英语English
Scopus ID	2-s2.0-0029145187
Citation statistics	Cited Times:72[WOS] [WOS Record] [Related Records in WOS]
Document Type	Journal article
Identifier	http://repository.uic.edu.cn/handle/39GCC9TT/11710
Collection	Research outside affiliated institution
Affiliation	Department of Biology, Hong Kong University of Science and Technology, Clear Water Bay, Kowloonm, Hong Kong
Recommended Citation GB/T 7714	Yung，Lisa Y.,Tsim，Siu Tai,Wong，Yung H. Stimulation of cAMP accumulation by the cloned Xenopus melatonin receptor through Gi and Gz proteins[J]. FEBS Letters, 1995, 372(1): 99-102.
APA	Yung，Lisa Y., Tsim，Siu Tai, & Wong，Yung H. (1995). Stimulation of cAMP accumulation by the cloned Xenopus melatonin receptor through Gi and Gz proteins. FEBS Letters, 372(1), 99-102.
MLA	Yung，Lisa Y.,et al."Stimulation of cAMP accumulation by the cloned Xenopus melatonin receptor through Gi and Gz proteins". FEBS Letters 372.1(1995): 99-102.

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