Details of Research Outputs

DNA cleavage using specific agents is essential for gaining insights into the mechanisms of DNA breakage, repair, and signal transduction. These cleaving agents hold significant promise as therapeutic drugs in biomedical applications. Recently, the development of biomimetic nanozymes – an innovative class of inorganic nanomaterials that exhibit enzyme-like catalytic activity – has paved the way for creating of novel DNA cleavage systems. Nanomaterials have been utilized as DNA cleavage agents due to their exceptional catalytic activity and stability. This review summarized the DNA cleavage activities and mechanisms with various nanomaterials. This review study will have great importance in designing the next-generation “CRISPR” nanomaterials for more biomedical and environmental applications.