Analysis of the transcriptomic profilings of Mandarin fish (Siniperca chuatsi) infected with Flavobacterium columnare with an emphasis on immune responses

doi:10.1016/j.fsi.2014.12.006

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Title	Analysis of the transcriptomic profilings of Mandarin fish (Siniperca chuatsi) infected with Flavobacterium columnare with an emphasis on immune responses
Creator	Zhou，Weidong 1; Zhang，Yulei 2,3; Wen，Yi 4; Ji，Wei 2,3; Zhou，Yang 3; Ji，Yachan 3; Liu，Xiaoling 3; Wang，Weimin 5; Asim，Muhammad 2,3; Liang，Xufang 2,5; Ai，Taoshan 1; Lin，Li 2,3,5
Date Issued	2015
Source Publication	Fish and Shellfish Immunology
ISSN	1050-4648
Volume	43 Issue:1 Pages:111-119
Abstract	Flavobacterium columnare (FC) is the causative pathogen of columnaris which has caused great economic loss in fish culture worldwide, including in Mandarin fish (Siniperca chuatsi) culture. In the present study, the transcriptomic profiles of the head kidneys from FC-infected and non-infected Mandarin fish were obtained using HiSeq™ 2000 (Illumina). Totally 31,168 unigenes with high quality were obtained. Genes involved in protein folding, metabolism and energy, immune responses, oxidoreductase activity, cell growth and death were identified as enriched classes. 1019 differently expressed genes between the two groups were identified, including 603 up-regulated and 416 down-regulated genes. 27 differently expressed immune related genes were scrutinized, including 17 up-regulated and 10 down-regulated genes. Six of the differently expressed genes were further validated by qRT-PCR. The roles of the immune related genes were discussed. Identification of the host genes in response to FC infection will shed a new light on the prevention of columnaris.
Keyword	Differently expressed genes Flavobacterium columnare Immune responses Siniperca chuatsi Transcriptome
DOI	10.1016/j.fsi.2014.12.006
URL	View source
Language	英语English
Scopus ID	2-s2.0-84942775711
Citation statistics	Cited Times:42[WOS] [WOS Record] [Related Records in WOS]
Document Type	Journal article
Identifier	http://repository.uic.edu.cn/handle/39GCC9TT/6467
Collection	Beijing Normal-Hong Kong Baptist University
Corresponding Author	Liang，Xufang
Affiliation	1.Wuhan Fishery Research Institute,Wuhan, Hubei,430207,China 2.Freshwater Aquaculture Collaborative Innovation Center of Hubei Province,Huazhong Agricultural University,Wuhan, Hubei,430070,China 3.Department of Aquatic Animal Medicine,College of Fisheries,Huazhong Agricultural University,Wuhan, Hubei,430070,China 4.Division of Science and Technology,Beijing Normal University,Hong Kong Baptist University United International College,Zhuhai, Guangdong,519085,China 5.China Key Lab of Freshwater Animal Breeding,Ministry of Agriculture,Wuhan, Hubei,430070,China
Recommended Citation GB/T 7714	Zhou，Weidong,Zhang，Yulei,Wen，Yiet al. Analysis of the transcriptomic profilings of Mandarin fish (Siniperca chuatsi) infected with Flavobacterium columnare with an emphasis on immune responses[J]. Fish and Shellfish Immunology, 2015, 43(1): 111-119.
APA	Zhou，Weidong., Zhang，Yulei., Wen，Yi., Ji，Wei., Zhou，Yang., .. & Lin，Li. (2015). Analysis of the transcriptomic profilings of Mandarin fish (Siniperca chuatsi) infected with Flavobacterium columnare with an emphasis on immune responses. Fish and Shellfish Immunology, 43(1), 111-119.
MLA	Zhou，Weidong,et al."Analysis of the transcriptomic profilings of Mandarin fish (Siniperca chuatsi) infected with Flavobacterium columnare with an emphasis on immune responses". Fish and Shellfish Immunology 43.1(2015): 111-119.

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