| Title | Chlorogenic acid exhibits cholesterol lowering and fatty liver attenuating properties by up-regulating the gene expression of PPAR-α in hypercholesterolemic rats induced with a high-cholesterol diet |
| Creator | |
| Date Issued | 2013 |
| Source Publication | Phytotherapy Research
 |
| ISSN | 0951-418X |
| Volume | 27Issue:4Pages:545-551 |
| Abstract | Hypercholesterolemia is a major risk factor for the development of cardiovascular disease and nonalcoholic fatty liver disease. Natural compounds have been proved to be useful in lowering serum cholesterol to slow down the progression of cardiovascular disease and nonalcoholic fatty liver disease. In the present study, the hypocholesterolemic and hepatoprotective effects of the dietary consumption of chlorogenic acid were investigated by monitoring plasma lipid profile (total cholesterol, triglycerides, high-density lipoprotein and low-density lipoprotein) in Sprague-Dawley rats fed with a normal diet, a high-cholesterol diet or a high-cholesterol diet supplemented with chlorogenic acid (1 or 10 mg/kg/day p.o.) for 28 days. Chlorogenic acid markedly altered the increased plasma total cholesterol and low-density lipoprotein but decreased high-density lipoprotein induced by a hypercholesterolemic diet with a dose-dependent improvement on both atherogenic index and cardiac risk factor. Lipid depositions in liver were attenuated significantly in hypercholesterolemic animals supplemented with chlorogenic acid. It is postulated that hypocholesterolemic effect is the primary beneficial effect given by chlorogenic acid, which leads to other secondary beneficial effects such as atheroscleroprotective, cardioprotective and hepatoprotective functions. The hypocholesterolemic functions of chlorogenic acid are probably due to the increase in fatty acids unitization in liver via the up-regulation of peroxisome proliferation-activated receptor α mRNA. Copyright © 2012 John Wiley & Sons, Ltd. |
| Keyword | chlorogenic acid cholesterol hypercholesterolemia lipid metabolism liver peroxisome proliferation-activated receptor α |
| DOI | 10.1002/ptr.4751 |
| URL | View source |
| Language | 英语English |
| Scopus ID | 2-s2.0-84876287225 |
| Citation statistics | |
| Document Type | Journal article |
| Identifier | http://repository.uic.edu.cn/handle/39GCC9TT/6549 |
| Collection | Beijing Normal-Hong Kong Baptist University |
| Affiliation | 1.Food Safety and Technology Research Centre,Department of Applied Biology and Chemical Technology,Hong Kong Polytechnic University,Hong Kong,Hong Kong 2.Programme of Food Science and Technology,Division of Science and Technology,BNU-HKBU United International College,Zhuhai,China 3.State Key Laboratory of Chinese Medicine and Molecular Pharmacology,Shenzhen,China |
| Recommended Citation GB/T 7714 | Wan，Chun Wai,Wong，Candy Ngai Yan,Pin，Wing Kwanet al. Chlorogenic acid exhibits cholesterol lowering and fatty liver attenuating properties by up-regulating the gene expression of PPAR-α in hypercholesterolemic rats induced with a high-cholesterol diet[J]. Phytotherapy Research, 2013, 27(4): 545-551. |
| APA | Wan，Chun Wai., Wong，Candy Ngai Yan., Pin，Wing Kwan., Wong，Marcus Ho Yin., Kwok，Ching Yee., .. & Chan，Shun Wan. (2013). Chlorogenic acid exhibits cholesterol lowering and fatty liver attenuating properties by up-regulating the gene expression of PPAR-α in hypercholesterolemic rats induced with a high-cholesterol diet. Phytotherapy Research, 27(4), 545-551. |
| MLA | Wan，Chun Wai,et al."Chlorogenic acid exhibits cholesterol lowering and fatty liver attenuating properties by up-regulating the gene expression of PPAR-α in hypercholesterolemic rats induced with a high-cholesterol diet". Phytotherapy Research 27.4(2013): 545-551. |
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