Nuclear factor of activated T cells 5 deficiency increases the severity of neuronal cell death in ischemic injury

doi:10.1159/000331899

Details of Research Outputs

Title	Nuclear factor of activated T cells 5 deficiency increases the severity of neuronal cell death in ischemic injury
Creator	Mak，Keri Man Chi 1; Lo，Amy Cheuk Yin 1,2; Lam，Amy Ka Man 1; Yeung，Patrick Ka Kit 3; Ko，Ben Chi Bun 3; Chung，Stephen Sum Man 4; Chung，Sookja Kim 1,2
Date Issued	2012
Source Publication	NeuroSignals
ISSN	1424-862X
Volume	20 Issue:4 Pages:237-251
Abstract	Nuclear factor of activated T cells 5 (NFAT5) has been implicated in regulating several genes that are thought to be neuroprotective in ischemic injury. Because of the embryonic lethality of NFAT5 knockout (NFAT5) mice, the heterozygous (NFAT5) mice were used to study the in vivo role of NFAT5 in hypoxia/ischemia (H/I) condition. The NFAT5 mice exhibited more severe neurological deficits, larger infarct area and edema formation associated with increased aquaporin 4 expressions in the brain. Under in vitro H/I condition, increased apoptotic cell death was found in NFAT5 neurons. Moreover, SMIT, a downstream to NFAT5, was upregulated in NFAT5 neurons, while the SMIT level could not be upregulated in NFAT5 neurons under H/I condition. The elevation of reactive oxygen species generation in NFAT5 neurons under H/I condition further confirmed that NFAT5 neurons were more susceptible to oxidative stress. The present study demonstrated that activation of NFAT5 and its downstream SMIT induction is important in protecting neurons from ischemia-induced oxidative stress. Copyright © 2012 S. Karger AG, Basel.
Keyword	Ischemia Knockout NFAT5 Oxidative stress SMIT
DOI	10.1159/000331899
URL	View source
Language	英语English
Scopus ID	2-s2.0-84869998602
Citation statistics	Cited Times:20[WOS] [WOS Record] [Related Records in WOS]
Document Type	Journal article
Identifier	http://repository.uic.edu.cn/handle/39GCC9TT/6579
Collection	Beijing Normal-Hong Kong Baptist University
Corresponding Author	Chung，Sookja Kim
Affiliation	1.Department of Anatomy,Li Ka Shing Faculty of Medicine,University of Hong Kong,21 Sassoon Road,Pokfulam, Hong Kong,Hong Kong 2.Research Center of Heart, Brain Hormone and Healthy Aging,Hong Kong 3.Department of Anatomical and Cellular Pathology,Chinese University of Hong Kong,Hong Kong, SAR,Hong Kong 4.Division of Science and Technology,United International College,Zhuhai,China
Recommended Citation GB/T 7714	Mak，Keri Man Chi,Lo，Amy Cheuk Yin,Lam，Amy Ka Manet al. Nuclear factor of activated T cells 5 deficiency increases the severity of neuronal cell death in ischemic injury[J]. NeuroSignals, 2012, 20(4): 237-251.
APA	Mak，Keri Man Chi., Lo，Amy Cheuk Yin., Lam，Amy Ka Man., Yeung，Patrick Ka Kit., Ko，Ben Chi Bun., .. & Chung，Sookja Kim. (2012). Nuclear factor of activated T cells 5 deficiency increases the severity of neuronal cell death in ischemic injury. NeuroSignals, 20(4), 237-251.
MLA	Mak，Keri Man Chi,et al."Nuclear factor of activated T cells 5 deficiency increases the severity of neuronal cell death in ischemic injury". NeuroSignals 20.4(2012): 237-251.

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