| Status | 已发表Published |
| Title | A peptide nanofibrous indicator for eye-detectable cancer cell identification |
| Creator | |
| Date Issued | 2013-03-25 |
| Source Publication | Small
 |
| ISSN | 1613-6810 |
| Volume | 9Issue:6Pages:920-926 |
| Abstract | A unique peptide nanofibrous indicator (NFI) is fabricated by mixing a borono-peptide with alizarin red S, followed by subsequent binding and self-assembly. The NFI thus obtained exhibits an intense response to sialyl Lewis X tetrasaccharide, which is overexpressed in human hepatocellular carcinoma cell lines. Importantly, this NFI has the capability of specifically recognizing human hepatocellular liver carcinoma (HepG2) cells through the eye-detectable color change resulting from strong binding-induced displacement. This novel technique for cancer cell identification through direct unaided eye judgment will open up an innovative platform for cancer cell detection. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
| Keyword | cancer cells diagnostics nanofibers peptides self-assembly |
| DOI | 10.1002/smll.201201928 |
| URL | View source |
| Indexed By | SCIE |
| Language | 英语English |
| WOS Research Area | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS Subject | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
| WOS ID | WOS:000316338800016 |
| Scopus ID | 2-s2.0-84875241628 |
| Citation statistics | |
| Document Type | Journal article |
| Identifier | http://repository.uic.edu.cn/handle/39GCC9TT/9109 |
| Collection | Research outside affiliated institution |
| Corresponding Author | Zhang, Xianzheng |
| Affiliation | 1.Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry,Wuhan University,Wuhan 430072,China 2.Department of Fiber Science and Apparel Design,Cornell University,Ithaca, NY 14853,United States |
| Recommended Citation GB/T 7714 | Chen, Changsheng,Xu, Xiaoding,Wang, Yaet al. A peptide nanofibrous indicator for eye-detectable cancer cell identification[J]. Small, 2013, 9(6): 920-926. |
| APA | Chen, Changsheng., Xu, Xiaoding., Wang, Ya., Yang, Juan., Jia, Huizhen., .. & Zhang, Xianzheng. (2013). A peptide nanofibrous indicator for eye-detectable cancer cell identification. Small, 9(6), 920-926. |
| MLA | Chen, Changsheng,et al."A peptide nanofibrous indicator for eye-detectable cancer cell identification". Small 9.6(2013): 920-926. |
| Files in This Item: | There are no files associated with this item. | |||||
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