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题名New Insights into Dietary Pterostilbene: Sources, Metabolism, and Health Promotion Effects
作者
发表日期2022-10-01
发表期刊Molecules
ISSN1420-3049
卷号27
期号19
摘要

Pterostilbene (PTS), a compound most abundantly found in blueberries, is a natural analog of resveratrol. Several plant species, such as peanuts and grapes, produce PTS. While resveratrol has been extensively studied for its antioxidant properties, recent evidence also points out the diverse therapeutic potential of PTS. Several studies have identified the robust pharmacodynamic features of PTS, including better intestinal absorption and elevated hepatic stability than resveratrol. Indeed, due to its higher bioavailability paired with reduced toxicity compared to other stilbenes, PTS has become an attractive drug candidate for the treatment of several disease conditions, including diabetes, cancer, cardiovascular disease, neurodegenerative disorders, and aging. This review article provides an extensive summary of the nutraceutical potential of PTS in various disease conditions while discussing the crucial mechanistic pathways implicated. In particular, we share insights from our studies about the Nrf2-mediated effect of PTS in diabetes and associated complications. Moreover, we elucidate the important sources of PTS and discuss in detail its pharmacokinetics and the range of formulations and routes of administration used across experimental studies and human clinical trials. Furthermore, this review also summarizes the strategies successfully used to improve dietary availability and the bio-accessibility of PTS.

关键词antioxidant bioavailability cancer diabetes Nrf2 pterostilbene resveratrol
DOI10.3390/molecules27196316
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收录类别SCIE
语种英语English
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
WOS类目Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS记录号WOS:000867140600001
Scopus入藏号2-s2.0-85139905052
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被引频次:62[WOS]   [WOS记录]     [WOS相关记录]
文献类型评论文章
条目标识符https://repository.uic.edu.cn/handle/39GCC9TT/10017
专题理工科技学院
通讯作者Ramkumar, Kunka Mohanram
作者单位
1.Department of Biotechnology,School of Bioengineering,SRM Institute of Science Technology,Kattankulathur,603 203,India
2.School of Chinese Medicine,LKS Faculty of Medicine,University of Hong Kong,10 Sassoon Road,999077,Hong Kong
3.Food Science and Technology Programme,Department of Life Sciences,BNU-HKBU United International College,Zhuhai,519087,China
推荐引用方式
GB/T 7714
Nagarajan, Sanjushree,Mohandas, Sundhar,Ganesan, Kumaret al. New Insights into Dietary Pterostilbene: Sources, Metabolism, and Health Promotion Effects. 2022.
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