状态 | 已发表Published |
题名 | New Insights into Dietary Pterostilbene: Sources, Metabolism, and Health Promotion Effects |
作者 | |
发表日期 | 2022-10-01 |
发表期刊 | Molecules |
ISSN | 1420-3049 |
卷号 | 27 |
期号 | 19 |
摘要 | Pterostilbene (PTS), a compound most abundantly found in blueberries, is a natural analog of resveratrol. Several plant species, such as peanuts and grapes, produce PTS. While resveratrol has been extensively studied for its antioxidant properties, recent evidence also points out the diverse therapeutic potential of PTS. Several studies have identified the robust pharmacodynamic features of PTS, including better intestinal absorption and elevated hepatic stability than resveratrol. Indeed, due to its higher bioavailability paired with reduced toxicity compared to other stilbenes, PTS has become an attractive drug candidate for the treatment of several disease conditions, including diabetes, cancer, cardiovascular disease, neurodegenerative disorders, and aging. This review article provides an extensive summary of the nutraceutical potential of PTS in various disease conditions while discussing the crucial mechanistic pathways implicated. In particular, we share insights from our studies about the Nrf2-mediated effect of PTS in diabetes and associated complications. Moreover, we elucidate the important sources of PTS and discuss in detail its pharmacokinetics and the range of formulations and routes of administration used across experimental studies and human clinical trials. Furthermore, this review also summarizes the strategies successfully used to improve dietary availability and the bio-accessibility of PTS. |
关键词 | antioxidant bioavailability cancer diabetes Nrf2 pterostilbene resveratrol |
DOI | 10.3390/molecules27196316 |
相关网址 | 查看来源 |
收录类别 | SCIE |
语种 | 英语English |
WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
WOS类目 | Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary |
WOS记录号 | WOS:000867140600001 |
Scopus入藏号 | 2-s2.0-85139905052 |
引用统计 | |
文献类型 | 评论文章 |
条目标识符 | https://repository.uic.edu.cn/handle/39GCC9TT/10017 |
专题 | 理工科技学院 |
通讯作者 | Ramkumar, Kunka Mohanram |
作者单位 | 1.Department of Biotechnology,School of Bioengineering,SRM Institute of Science Technology,Kattankulathur,603 203,India 2.School of Chinese Medicine,LKS Faculty of Medicine,University of Hong Kong,10 Sassoon Road,999077,Hong Kong 3.Food Science and Technology Programme,Department of Life Sciences,BNU-HKBU United International College,Zhuhai,519087,China |
推荐引用方式 GB/T 7714 | Nagarajan, Sanjushree,Mohandas, Sundhar,Ganesan, Kumaret al. New Insights into Dietary Pterostilbene: Sources, Metabolism, and Health Promotion Effects. 2022. |
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