Regulation of cell proliferation by G proteins

doi:10.1038/sj.onc.1202242

科研成果详情

题名	Regulation of cell proliferation by G proteins
作者	Dhanasekaran，N.; Tsim，Siu Tai; Dermott，Jonathan M.; Onesime，Djamila
发表日期	1998-09-17
发表期刊	Oncogene
ISSN	0950-9232
卷号	17
期号	11 REV. ISS. 1
页码	1383-1394
摘要	G Proteins provide signal transduction mechanisms to seven transmembrane receptors. Recent studies have indicated that the α-subunits as well as the βγ-subunits of these proteins regulate several critical signaling pathways involved in cell proliferation, differentiation and apoptosis. Of the 17 α-subunits that have been cloned, at least ten of them have been shown to couple mitogenic signaling in fibroblast cells. Activating mutations in Gα(s), Gα(i2), and Gα have been correlated with different types of tumors. In addition, the ability of the βγ-subunits to activate mitogenic pathways in different cell-types has been defined. The present review briefly summarizes the diverse and novel signaling pathways regulated by the α- as well as the βγ-subunits of G proteins in regulating cell proliferation.
关键词	ERK G proteins JNK Oncogene Ras Signaling
DOI	10.1038/sj.onc.1202242
相关网址	查看来源
语种	英语English
Scopus入藏号	2-s2.0-0032541632
引用统计	被引频次：128[WOS] [WOS记录] [WOS相关记录]
文献类型	评论文章
条目标识符	https://repository.uic.edu.cn/handle/39GCC9TT/11704
专题	个人在本单位外知识产出
通讯作者	Dhanasekaran，N.
作者单位	Fels Inst. Cancer Res./Molec. Biol.,Temple University School of Medicine,Philadelphia, PA 19140,United States
推荐引用方式 GB/T 7714	Dhanasekaran，N.,Tsim，Siu Tai,Dermott，Jonathan M.et al. Regulation of cell proliferation by G proteins. 1998.