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题名Breast cancer image classification based on H&E staining using a causal attention graph neural network model
作者
发表日期2025-07
发表期刊Medical and Biological Engineering and Computing
ISSN/eISSN0140-0118
卷号63期号:7页码:1965-1979
摘要

Breast cancer image classification remains a challenging task due to the high-resolution nature of pathological images and their complex feature distributions. Graph neural networks (GNNs) offer promising capabilities to capture local structural information but often suffer from limited generalization and reliance on shortcut features. This study proposes a novel causal discovery attention-based graph neural network (CDA-GNN) model. The model converts high-resolution image data into graph data using superpixel segmentation and employs a causal attention mechanism to identify and utilize key causal features. A backdoor adjustment strategy further disentangles causal features from shortcut features, enhancing model interpretability and robustness. Experimental evaluations on the 2018 BACH breast cancer image dataset demonstrate that CDA-GNN achieves a classification accuracy of 86.36%. Additional metrics, including F1-score and ROC, validate the superior performance and generalization of the proposed approach. The CDA-GNN model, with its powerful automated cancer image analysis capabilities and strong interpretability, provides an effective tool for clinical applications. It significantly reduces the workload of healthcare professionals while facilitating the early detection and diagnosis of breast cancer, thereby improving diagnostic efficiency and accuracy.

关键词Breast cancer Causal intervention Graph classification Graph neural network
DOI10.1007/s11517-025-03303-3
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收录类别SCIE
语种英语English
WOS研究方向Computer Science ; Engineering ; Mathematical & Computational Biology ; Medical Informatics
WOS类目Computer Science, Interdisciplinary Applications ; Engineering, Biomedical ; Mathematical & Computational Biology ; Medical Informatics
WOS记录号WOS:001412764500001
Scopus入藏号2-s2.0-85217656791
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符https://repository.uic.edu.cn/handle/39GCC9TT/13250
专题北师香港浸会大学
通讯作者Zhang, Zhongrong
作者单位
1.School of Mathematics and Physics,Lanzhou Jiaotong University,Lanzhou City,No. 88 Anning West Road, Anning District, Gansu Province,China
2.Artificial Intelligence,Beijing Normal University-Hong Kong Baptist University United International College,Zhuhai,China
3.Lanzhou Petrochemical General Hospital,Lanzhou,China
推荐引用方式
GB/T 7714
Chang, Xiaoya,Zhang, Zhongrong,Sun, Jianguoet al. Breast cancer image classification based on H&E staining using a causal attention graph neural network model[J]. Medical and Biological Engineering and Computing, 2025, 63(7): 1965-1979.
APA Chang, Xiaoya, Zhang, Zhongrong, Sun, Jianguo, Lin, Kang, & Song, Ping' an. (2025). Breast cancer image classification based on H&E staining using a causal attention graph neural network model. Medical and Biological Engineering and Computing, 63(7), 1965-1979.
MLA Chang, Xiaoya,et al."Breast cancer image classification based on H&E staining using a causal attention graph neural network model". Medical and Biological Engineering and Computing 63.7(2025): 1965-1979.
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