Mo-terminated edges in two-dimensional molybdenum disulfide for site-specific hydrolysis and DNA cleavage

doi:10.1016/j.mattod.2025.03.020

科研成果详情

题名	Mo-terminated edges in two-dimensional molybdenum disulfide for site-specific hydrolysis and DNA cleavage
作者	Wang，Cong 1; Wu，Menghan 1; Li，Muqing 2; Zhao，Yingcan 3; Zhao，Mingchuang 1; Zhang，Yunhao 2; Bai，Yichao 1; Gao，Jianxiang 1; Wang，Xiaoxia 1; Tian，Xilin 6; Zhang，Han 6; Chang，Liang 1; Zou，Xiaolong 2; Liu，Bilu 2; Kang，Feiyu 4; Terrones，Mauricio 5; Lei，Yu 1
发表日期	2025-07-01
发表期刊	Materials Today
ISSN/eISSN	1369-7021
卷号	86 页码:162-171
摘要	The hydrolysis of DNA serves as the foundational principle for gene engineering that enable precise gene cleavage at the molecular level. This process typically occurs in biological nucleases, which exhibit nucleobase-selective and catalytic hydrolysis capabilities rarely replicated in abiotic nanomaterials. Here, we demonstrate that molybdenum-terminated (Mo-terminated) edges of molybdenum disulfide (MoS) possess the unique ability to abstract a proton (H) from water molecules, thereby facilitating catalytic hydrolysis reactions that cleave the phosphodiester bonds in DNA through the action of hydroxide ions. The enhanced proton absorption at Mo-terminated edges of MoS significantly reduces the activation energy required for the DNA hydrolysis reaction. Furthermore, the favorable interaction between the Mo-terminated edges and thymine nucleobases promotes both charge transfer and P-O bond cleavage, enabling targeted DNA hydrolysis at 'TTTTTTT' sequences under dark conditions. This discovery underscores the potential of MoS as a stable, efficient nanosystem for precise genetic editing, heralding advanced applications in the field of gene engineering.
DOI	10.1016/j.mattod.2025.03.020
URL	查看来源
语种	英语English
Scopus入藏号	2-s2.0-105001959677
引用统计
文献类型	期刊论文
条目标识符	https://repository.uic.edu.cn/handle/39GCC9TT/13252
专题	北师香港浸会大学
通讯作者	Zhao，Yingcan
作者单位	1.Institute of Materials Research,Shenzhen Key Laboratory of Advanced Layered Materials for Value-added Applications,Guangdong Provincial Key Laboratory of Thermal Management Engineering and Materials & Center of Double Helix,Tsinghua Shenzhen International Graduate School,Tsinghua University,Shenzhen,518055,China 2.Institute of Materials Research & Shenzhen Geim Graphene Center,Shenzhen Key Laboratory of Advanced Layered Materials for Value-added Applications,Tsinghua-Berkeley Shenzhen Institute and Tsinghua Shenzhen International Graduate School,Tsinghua University,Shenzhen,518055,China 3.Environmental Science Program,Department of Life Sciences,Beijing Normal University-Hong Kong Baptist University United International College,Guangdong,519087,China 4.Shenzhen All-Solid-State Lithium Battery Electrolyte Engineering Research Center and Shenzhen Geim Graphene Center,Institute of Materials Research (IMR),Tsinghua Shenzhen International Graduate School,Tsinghua University,Shenzhen,518055,China 5.Department of Physics,Department of Chemistry,Department of Materials Sciences,Center for 2-Dimensional and Layered Materials,The Pennsylvania State University,University Park,16802,United States 6.International Collaborative Laboratory of 2D,Materials for Optoelectronics Science and Technology of Ministry of Education,Institute of Microscale Optoelectronics,Shenzhen University,Shenzhen,518060,China
通讯作者单位	北师香港浸会大学
推荐引用方式 GB/T 7714	Wang，Cong,Wu，Menghan,Li，Muqinget al. Mo-terminated edges in two-dimensional molybdenum disulfide for site-specific hydrolysis and DNA cleavage[J]. Materials Today, 2025, 86: 162-171.
APA	Wang，Cong., Wu，Menghan., Li，Muqing., Zhao，Yingcan., Zhao，Mingchuang., .. & Lei，Yu. (2025). Mo-terminated edges in two-dimensional molybdenum disulfide for site-specific hydrolysis and DNA cleavage. Materials Today, 86, 162-171.
MLA	Wang，Cong,et al."Mo-terminated edges in two-dimensional molybdenum disulfide for site-specific hydrolysis and DNA cleavage". Materials Today 86(2025): 162-171.