Characterization of uniaxial stiffness of extracellular matrix embedded with magnetic beads via bio-conjugation and under the influence of an external magnetic field

doi:10.1016/j.jmbbm.2013.11.012

科研成果详情

发表状态	已发表Published
题名	Characterization of uniaxial stiffness of extracellular matrix embedded with magnetic beads via bio-conjugation and under the influence of an external magnetic field
作者	Herath, Sahan C.B.1,2; Du, Yue 1,2; Wang, Dongan Ano 3; Liao, Kin 3; Wang, Qingguo5 ; Asada, Haruhiko Harry 2,4; Chen, Peter Chao-Yu 1,2
发表日期	2014
发表期刊	Journal of the Mechanical Behavior of Biomedical Materials
ISSN/eISSN	1751-6161
卷号	30 页码:253-265
摘要	In this paper, we study the deformation, and experimentally quantify the change in stiffness, of an extracellular matrix (ECM) embedded with magnetic beads that are bio-conjugated with the collagen fibers and under the influence of an external magnetic field. We develop an analytical model of the viscoelastic behavior of this modified ECM, and design and implement a stretch test to quantify (based on statistically meaningful experiment data) the resulting changes in its stiffness induced by the external magnetic field. The analytical results are in close agreement with that obtained from the experiments. We discuss the implication of these results that point to the possibility of creating desired stiffness gradients in an ECM in vitro to influence cell behavior. © 2013 Elsevier Ltd.
DOI	10.1016/j.jmbbm.2013.11.012
URL	查看来源
收录类别	SCIE
语种	英语English
WOS研究方向	Engineering ; Materials Science
WOS类目	Engineering, Biomedical ; Materials Science, Biomaterials
WOS记录号	WOS:000331493900026
引用统计	被引频次：6[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://repository.uic.edu.cn/handle/39GCC9TT/3768
专题	个人在本单位外知识产出
作者单位	1.Department of Mechanical Engineering, National University of Singapore, Singapore, Singapore 2.Biosystem and Micromechanics Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology Program, SGP, Singapore 3.Division of Bioengineering, Nanyang Technological University, Singapore, Singapore 4.Department of Mechanical Engineering, Massachusetts Institute of Technology, MA, United States 5.Department of Electrical and Computer Engineering, National University of Singapore, Singapore, Singapore
推荐引用方式 GB/T 7714	Herath, Sahan C.B.,Du, Yue,Wang, Dongan Anoet al. Characterization of uniaxial stiffness of extracellular matrix embedded with magnetic beads via bio-conjugation and under the influence of an external magnetic field[J]. Journal of the Mechanical Behavior of Biomedical Materials, 2014, 30: 253-265.
APA	Herath, Sahan C.B., Du, Yue., Wang, Dongan Ano., Liao, Kin., Wang, Qingguo., .. & Chen, Peter Chao-Yu. (2014). Characterization of uniaxial stiffness of extracellular matrix embedded with magnetic beads via bio-conjugation and under the influence of an external magnetic field. Journal of the Mechanical Behavior of Biomedical Materials, 30, 253-265.
MLA	Herath, Sahan C.B.,et al."Characterization of uniaxial stiffness of extracellular matrix embedded with magnetic beads via bio-conjugation and under the influence of an external magnetic field". Journal of the Mechanical Behavior of Biomedical Materials 30(2014): 253-265.