Effects of common prebiotics on iron status and production of colonic short-chain fatty acids in anemic rats

doi:10.1016/j.fshw.2021.02.024

科研成果详情

题名	Effects of common prebiotics on iron status and production of colonic short-chain fatty acids in anemic rats
作者	Zhang，Fan 1; Yung，Ken K.L.2; KongYeung，Chi 3
发表日期	2021-05-01
发表期刊	Food Science and Human Wellness
卷号	10 期号:3 页码:327-334
摘要	Prebiotics may enhance iron absorption, and one plausible mechanism involves the production of short-chain fatty acids (SCFA) in the colon by intestinal microflora. The objectives of this study were to determine the effects of common commercially-available prebiotics including fructooligosaccharide (FOS), inulin, FOS-inulin mixture, galactooligosaccharide (GOS), and lactulose on the iron status of anemic rats, and to monitor changes in the production of colonic SCFA. Anemic Sprague-Dawley rats receiving a low-iron diet (12 μg Fe/g diet) were supplemented with or without prebiotics (5% m/V in drinking water) for 5 weeks. Hemoglobin concentration in rats supplemented with GOS after 3 weeks (4.3 g/dL) was significantly higher than rats without supplementation (3.7 g/dL), while FOS also significantly increased hemoglobin concentration after 4 weeks (4.1 g/dL vs. 3.7 g/dL). All other prebiotics showed no effects. Anemic rats showed lower overall SCFA production in the colon than normal rats, and only FOS significantly increased the production of the three main SCFA (acetic acid, propionic acid and isobutyric acid) identified in anemic rats, with other prebiotics showing no noticeable trends. Our results suggest that GOS and FOS may slightly improve iron status of anemic rats, but the role of SCFA in the colon is not clear.
关键词	Iron Non-digestible oligosaccharides Prebiotics Rat Short-chain fatty acids
DOI	10.1016/j.fshw.2021.02.024
URL	查看来源
语种	英语English
Scopus入藏号	2-s2.0-85104360792
引用统计	被引频次：11[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://repository.uic.edu.cn/handle/39GCC9TT/6014
专题	北师香港浸会大学
通讯作者	KongYeung，Chi
作者单位	1.Division of Science and Technology,BNU-HKBU United International College,Zhuhai,Guangdong,China 2.Department of Biology,Hong Kong Baptist University,Hong Kong,China 3.Animal Science Department,California Polytechnic State University,San Luis Obispo,California,United States
第一作者单位	北师香港浸会大学
推荐引用方式 GB/T 7714	Zhang，Fan,Yung，Ken K.L.,KongYeung，Chi. Effects of common prebiotics on iron status and production of colonic short-chain fatty acids in anemic rats[J]. Food Science and Human Wellness, 2021, 10(3): 327-334.
APA	Zhang，Fan, Yung，Ken K.L., & KongYeung，Chi. (2021). Effects of common prebiotics on iron status and production of colonic short-chain fatty acids in anemic rats. Food Science and Human Wellness, 10(3), 327-334.
MLA	Zhang，Fan,et al."Effects of common prebiotics on iron status and production of colonic short-chain fatty acids in anemic rats". Food Science and Human Wellness 10.3(2021): 327-334.