题名 | Effects of common prebiotics on iron status and production of colonic short-chain fatty acids in anemic rats |
作者 | |
发表日期 | 2021-05-01 |
发表期刊 | Food Science and Human Wellness
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卷号 | 10期号:3页码:327-334 |
摘要 | Prebiotics may enhance iron absorption, and one plausible mechanism involves the production of short-chain fatty acids (SCFA) in the colon by intestinal microflora. The objectives of this study were to determine the effects of common commercially-available prebiotics including fructooligosaccharide (FOS), inulin, FOS-inulin mixture, galactooligosaccharide (GOS), and lactulose on the iron status of anemic rats, and to monitor changes in the production of colonic SCFA. Anemic Sprague-Dawley rats receiving a low-iron diet (12 μg Fe/g diet) were supplemented with or without prebiotics (5% m/V in drinking water) for 5 weeks. Hemoglobin concentration in rats supplemented with GOS after 3 weeks (4.3 g/dL) was significantly higher than rats without supplementation (3.7 g/dL), while FOS also significantly increased hemoglobin concentration after 4 weeks (4.1 g/dL vs. 3.7 g/dL). All other prebiotics showed no effects. Anemic rats showed lower overall SCFA production in the colon than normal rats, and only FOS significantly increased the production of the three main SCFA (acetic acid, propionic acid and isobutyric acid) identified in anemic rats, with other prebiotics showing no noticeable trends. Our results suggest that GOS and FOS may slightly improve iron status of anemic rats, but the role of SCFA in the colon is not clear. |
关键词 | Iron Non-digestible oligosaccharides Prebiotics Rat Short-chain fatty acids |
DOI | 10.1016/j.fshw.2021.02.024 |
URL | 查看来源 |
语种 | 英语English |
Scopus入藏号 | 2-s2.0-85104360792 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://repository.uic.edu.cn/handle/39GCC9TT/6014 |
专题 | 北师香港浸会大学 |
通讯作者 | KongYeung,Chi |
作者单位 | 1.Division of Science and Technology,BNU-HKBU United International College,Zhuhai,Guangdong,China 2.Department of Biology,Hong Kong Baptist University,Hong Kong,China 3.Animal Science Department,California Polytechnic State University,San Luis Obispo,California,United States |
第一作者单位 | 北师香港浸会大学 |
推荐引用方式 GB/T 7714 | Zhang,Fan,Yung,Ken K.L.,KongYeung,Chi. Effects of common prebiotics on iron status and production of colonic short-chain fatty acids in anemic rats[J]. Food Science and Human Wellness, 2021, 10(3): 327-334. |
APA | Zhang,Fan, Yung,Ken K.L., & KongYeung,Chi. (2021). Effects of common prebiotics on iron status and production of colonic short-chain fatty acids in anemic rats. Food Science and Human Wellness, 10(3), 327-334. |
MLA | Zhang,Fan,et al."Effects of common prebiotics on iron status and production of colonic short-chain fatty acids in anemic rats". Food Science and Human Wellness 10.3(2021): 327-334. |
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