科研成果详情

题名Epac2-deficiency leads to more severe retinal swelling, glial reactivity and oxidative stress in transient middle cerebral artery occlusion induced ischemic retinopathy
作者
发表日期2015-06-20
发表期刊Science China Life Sciences
ISSN/eISSN1674-7305
卷号58期号:6页码:521-530
摘要Ischemia occurs in diabetic retinopathy with neuronal loss, edema, glial cell reactivity and oxidative stress. Epacs, consisting of Epac1 and Epac2, are cAMP mediators playing important roles in maintenance of endothelial barrier and neuronal functions. To investigate the roles of Epacs in the pathogenesis of ischemic retinopathy, transient middle cerebral artery occlusion (tMCAO) was performed on Epac1-deficient (Epac1-/-) mice, Epac2-deficient (Epac2-/-) mice, and their wild type counterparts (Epac1+/+ and Epac2+/+). Two-hour occlusion and 22-hour reperfusion were conducted to induce ischemia/reperfusion injury to the retina. After tMCAO, the contralateral retinae displayed similar morphology between different genotypes. Neuronal loss, retinal edema and increase in immunoreactivity for aquaporin 4 (AQP4), glial fibrillary acidic protein (GFAP), peroxiredoxin 6 (Prx6) were observed in ipsilateral retinae. Epac2-/- ipsilateral retinae showed more neuronal loss in retinal ganglion cell layer, increased retinal thickness and stronger immunostaining of AQP4, GFAP, and Prx6 than those of Epac2+/+. However, Epac1-/- ipsilateral retinae displayed similar pathology as those in Epac1+/+ mice. Our observations suggest that Epac2-deficiency led to more severe ischemic retinopathy after retinal ischemia/reperfusion injury.
关键词Epac ischemia retina retinopathy
DOI10.1007/s11427-015-4860-1
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语种英语English
Scopus入藏号2-s2.0-84931566593
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被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符https://repository.uic.edu.cn/handle/39GCC9TT/6450
专题北师香港浸会大学
通讯作者Chung,Sookja Kim
作者单位
1.Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong,Hong Kong,China
2.Department of Ophthalmology, Li Ka Shing Faculty of Medicine, The University of Hong Kong,Hong Kong,China
3.Research Centre of Heart, Brain, Hormone and Healthy Aging, Li Ka Shing Faculty of Medicine, The University of Hong Kong,Hong Kong,China
4.Division of Science and Technology, United International College,Zhuhai,519085,China
5.State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong,Hong Kong,China
推荐引用方式
GB/T 7714
Liu,Jin,Yeung,Patrick Ka Kit,Cheng,Luet al. Epac2-deficiency leads to more severe retinal swelling, glial reactivity and oxidative stress in transient middle cerebral artery occlusion induced ischemic retinopathy[J]. Science China Life Sciences, 2015, 58(6): 521-530.
APA Liu,Jin, Yeung,Patrick Ka Kit, Cheng,Lu, Lo,Amy Cheuk Yin, Chung,Stephen Sum Man, & Chung,Sookja Kim. (2015). Epac2-deficiency leads to more severe retinal swelling, glial reactivity and oxidative stress in transient middle cerebral artery occlusion induced ischemic retinopathy. Science China Life Sciences, 58(6), 521-530.
MLA Liu,Jin,et al."Epac2-deficiency leads to more severe retinal swelling, glial reactivity and oxidative stress in transient middle cerebral artery occlusion induced ischemic retinopathy". Science China Life Sciences 58.6(2015): 521-530.
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