科研成果详情

题名Embryonic lethality in mice lacking the nuclear factor of activated t cells 5 protein due to impaired cardiac development and function
作者
发表日期2011
发表期刊PLoS ONE
卷号6期号:7
摘要Nuclear factor of activated T cells 5 protein (NFAT5) is thought to be important for cellular adaptation to osmotic stress by regulating the transcription of genes responsible for the synthesis or transport of organic osmolytes. It is also thought to play a role in immune function, myogenesis and cancer invasion. To better understand the function of NFAT5, we developed NFAT5 gene knockout mice. Homozygous NFAT5 null (NFAT5) mouse embryos failed to develop normally and died after 14.5 days of embryonic development (E14.5). The embryos showed peripheral edema, and abnormal heart development as indicated by thinner ventricular wall and reduced cell density at the compact and trabecular areas of myocardium. This is associated with reduced level of proliferating cell nuclear antigen and increased caspase-3 in these tissues. Cardiomyocytes from E14.5 NFAT5 embryos showed a significant reduction of beating rate and abnormal Ca signaling profile as a consequence of reduced sarco(endo)plasmic reticulum Ca-ATPase (SERCA) and ryanodine receptor (RyR) expressions. Expression of NFAT5 target genes, such as HSP 70 and SMIT were reduced in NFAT5 cardiomyocytes. Our findings demonstrated an essential role of NFAT5 in cardiac development and Ca signaling. Cardiac failure is most likely responsible for the peripheral edema and death of NFAT5 embryos at E14.5 days. © 2011 Mak et al.
DOI10.1371/journal.pone.0019186
URL查看来源
语种英语English
Scopus入藏号2-s2.0-79960196928
引用统计
被引频次:37[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符https://repository.uic.edu.cn/handle/39GCC9TT/6617
专题北师香港浸会大学
作者单位
1.Department of Anatomy,Li Ka Shing Faculty of Medicine,The University of Hong Kong,Hong Kong SAR,China
2.Division of Science and Technology,United International College,Zhuhai, Guandong,China
3.Department of Anatomical and Cellular Pathology,The Chinese University of Hong Kong,Hong Kong SAR,Hong Kong
推荐引用方式
GB/T 7714
Mak,Man Chi,Lam,Ka Man,Chan,Ping Keiet al. Embryonic lethality in mice lacking the nuclear factor of activated t cells 5 protein due to impaired cardiac development and function[J]. PLoS ONE, 2011, 6(7).
APA Mak,Man Chi., Lam,Ka Man., Chan,Ping Kei., Lau,Yu Bond., Tang,Wai Ho., .. & Chung,Sookja Kim. (2011). Embryonic lethality in mice lacking the nuclear factor of activated t cells 5 protein due to impaired cardiac development and function. PLoS ONE, 6(7).
MLA Mak,Man Chi,et al."Embryonic lethality in mice lacking the nuclear factor of activated t cells 5 protein due to impaired cardiac development and function". PLoS ONE 6.7(2011).
条目包含的文件
条目无相关文件。
个性服务
查看访问统计
谷歌学术
谷歌学术中相似的文章
[Mak,Man Chi]的文章
[Lam,Ka Man]的文章
[Chan,Ping Kei]的文章
百度学术
百度学术中相似的文章
[Mak,Man Chi]的文章
[Lam,Ka Man]的文章
[Chan,Ping Kei]的文章
必应学术
必应学术中相似的文章
[Mak,Man Chi]的文章
[Lam,Ka Man]的文章
[Chan,Ping Kei]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。