Structural characterization, and in vitro hypoglycemic activity of a polysaccharide from the mushroom Cantharellus yunnanensis

doi:10.1016/j.ijbiomac.2023.127200

科研成果详情

发表状态	已发表Published
题名	Structural characterization, and in vitro hypoglycemic activity of a polysaccharide from the mushroom Cantharellus yunnanensis
作者	Tian, Run 1,2; Zhang, Yu-Zhuo 3; Cheng, Xianbo 4; Xu, Baojun5 ; Wu, Haitao 6; Liang, Zhi-Qun 7; Rahman, Muyassar 8; Wang, Yong 1; Zeng, Nian-Kai 1,2
发表日期	2023-12-31
发表期刊	International Journal of Biological Macromolecules
ISSN/eISSN	0141-8130
卷号	253
摘要	A polysaccharide CY-2 from C. yunnanensis was obtained through a process of consecutive water extraction, alcohol precipitation, and DEAE-52 fast-flow chromatography. CY-2, with an average molecular weight of 2.69 × 10 Da mainly consisted of glucose and mannose with a molar ratio of 33.5: 56.9. Infrared spectrum (IR), methylation analysis, and nuclear magnetic resonance (NMR) results revealed that CY-2 may have a backbone consisting of →6)-α-D-Manp-(1 → 3)-β-D-Glcp-(1→, and branch chain β-D-Glcp-(1→. Meanwhile, CY-2 had a higher inhibition rate on α-glucosidase activity compared with other fractions (CY-0, CY-1, and CY-4) and was a mixed competitive inhibitor. In addition, CY-2 at the concentration of 10 μg/mL presented a superior power to improve glucose consumption and metabolism in HepG2 cells compared with metformin. Overall, these findings highlight the potential value of CY-2 as a hypoglycemic agent.
关键词	Hypoglycemic effect Physicochemical properties Structure elucidation
DOI	10.1016/j.ijbiomac.2023.127200
URL	查看来源
收录类别	SCIE
语种	英语English
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science
WOS记录号	WOS:001087990800001
Scopus入藏号	2-s2.0-85173027150
引用统计
文献类型	期刊论文
条目标识符	https://repository.uic.edu.cn/handle/39GCC9TT/11073
专题	理工科技学院
通讯作者	Wang, Yong; Zeng, Nian-Kai
作者单位	1.Key Laboratory of Tropical Translational Medicine of Ministry of Education,Hainan Provincial Key Laboratory for Research and Development on Tropical Herbs,School of Pharmacy,Hainan Medical University,Haikou,571199,China 2.Ministry of Education Key Laboratory for Ecology of Tropical Islands,Key Laboratory of Tropical Animal and Plant Ecology of Hainan Province,College of Life Sciences,Hainan Normal University,Haikou,571158,China 3.Gongyi Public Traditional Chinese Medicine Hospital,Henan Province,Zhengzhou,451200,China 4.Dietary Fiber Isolation and Structural Characterization Laboratory,Guangxi Vocational College of Technology and Business,Nanning,530003,China 5.Food Science and Technology Program,Department of Life Sciences,BNU-HKBU United International College,Zhuhai,Guangdong,519087,China 6.Science and Technology Innovation Center,Guangzhou University of Chinese Medicine,Guangzhou,510405,China 7.College of Science,Hainan University,Haikou,570228,China 8.General Hospital of the Third Division of Xinjiang Production and Construction Corps,Kashgar,Kashgar Hospital District,844000,China
推荐引用方式 GB/T 7714	Tian, Run,Zhang, Yu-Zhuo,Cheng, Xianboet al. Structural characterization, and in vitro hypoglycemic activity of a polysaccharide from the mushroom Cantharellus yunnanensis[J]. International Journal of Biological Macromolecules, 2023, 253.
APA	Tian, Run., Zhang, Yu-Zhuo., Cheng, Xianbo., Xu, Baojun., Wu, Haitao., .. & Zeng, Nian-Kai. (2023). Structural characterization, and in vitro hypoglycemic activity of a polysaccharide from the mushroom Cantharellus yunnanensis. International Journal of Biological Macromolecules, 253.
MLA	Tian, Run,et al."Structural characterization, and in vitro hypoglycemic activity of a polysaccharide from the mushroom Cantharellus yunnanensis". International Journal of Biological Macromolecules 253(2023).