| Status | 已发表Published |
| Title | Structural characterization, and in vitro hypoglycemic activity of a polysaccharide from the mushroom Cantharellus yunnanensis |
| Creator | |
| Date Issued | 2023-12-31 |
| Source Publication | International Journal of Biological Macromolecules
 |
| ISSN | 0141-8130 |
| Volume | 253 |
| Abstract | A polysaccharide CY-2 from C. yunnanensis was obtained through a process of consecutive water extraction, alcohol precipitation, and DEAE-52 fast-flow chromatography. CY-2, with an average molecular weight of 2.69 × 10 Da mainly consisted of glucose and mannose with a molar ratio of 33.5: 56.9. Infrared spectrum (IR), methylation analysis, and nuclear magnetic resonance (NMR) results revealed that CY-2 may have a backbone consisting of →6)-α-D-Manp-(1 → 3)-β-D-Glcp-(1→, and branch chain β-D-Glcp-(1→. Meanwhile, CY-2 had a higher inhibition rate on α-glucosidase activity compared with other fractions (CY-0, CY-1, and CY-4) and was a mixed competitive inhibitor. In addition, CY-2 at the concentration of 10 μg/mL presented a superior power to improve glucose consumption and metabolism in HepG2 cells compared with metformin. Overall, these findings highlight the potential value of CY-2 as a hypoglycemic agent. |
| Keyword | Hypoglycemic effect Physicochemical properties Structure elucidation |
| DOI | 10.1016/j.ijbiomac.2023.127200 |
| URL | View source |
| Indexed By | SCIE |
| Language | 英语English |
| WOS Research Area | Biochemistry & Molecular Biology ; Chemistry ; Polymer Science |
| WOS Subject | Biochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science |
| WOS ID | WOS:001087990800001 |
| Scopus ID | 2-s2.0-85173027150 |
| Citation statistics | |
| Document Type | Journal article |
| Identifier | http://repository.uic.edu.cn/handle/39GCC9TT/11073 |
| Collection | Faculty of Science and Technology |
| Corresponding Author | Wang, Yong; Zeng, Nian-Kai |
| Affiliation | 1.Key Laboratory of Tropical Translational Medicine of Ministry of Education,Hainan Provincial Key Laboratory for Research and Development on Tropical Herbs,School of Pharmacy,Hainan Medical University,Haikou,571199,China 2.Ministry of Education Key Laboratory for Ecology of Tropical Islands,Key Laboratory of Tropical Animal and Plant Ecology of Hainan Province,College of Life Sciences,Hainan Normal University,Haikou,571158,China 3.Gongyi Public Traditional Chinese Medicine Hospital,Henan Province,Zhengzhou,451200,China 4.Dietary Fiber Isolation and Structural Characterization Laboratory,Guangxi Vocational College of Technology and Business,Nanning,530003,China 5.Food Science and Technology Program,Department of Life Sciences,BNU-HKBU United International College,Zhuhai,Guangdong,519087,China 6.Science and Technology Innovation Center,Guangzhou University of Chinese Medicine,Guangzhou,510405,China 7.College of Science,Hainan University,Haikou,570228,China 8.General Hospital of the Third Division of Xinjiang Production and Construction Corps,Kashgar,Kashgar Hospital District,844000,China |
| Recommended Citation GB/T 7714 | Tian, Run,Zhang, Yu-Zhuo,Cheng, Xianboet al. Structural characterization, and in vitro hypoglycemic activity of a polysaccharide from the mushroom Cantharellus yunnanensis[J]. International Journal of Biological Macromolecules, 2023, 253. |
| APA | Tian, Run., Zhang, Yu-Zhuo., Cheng, Xianbo., Xu, Baojun., Wu, Haitao., .. & Zeng, Nian-Kai. (2023). Structural characterization, and in vitro hypoglycemic activity of a polysaccharide from the mushroom Cantharellus yunnanensis. International Journal of Biological Macromolecules, 253. |
| MLA | Tian, Run,et al."Structural characterization, and in vitro hypoglycemic activity of a polysaccharide from the mushroom Cantharellus yunnanensis". International Journal of Biological Macromolecules 253(2023). |
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