Details of Research Outputs

Trianthema portulacastrum L. (Aizoaceae) commonly called as black pigweed or giant pigweed, which is a yearly herb, utilized as purgative, pain relieving, stomachic and provide as alternative heal for lung disease, cardiovascular disease, anemia and edema. In the Ayurvedic system of medicine, the plant is used in the treatment of inflammation in the peripheral organs, uteralgia and cough. Taking into account exploratory study, the present review aims to provide up-to date data about the routine uses, phytochemistry, and pharmacological actions of T. portulacastrum to explore their therapeutic value for future clinical settings. All data of T. portulacastrum were collected from library database and electronic search (ScienceDirect, Pubmed, and GoogleScholar). The different pharmacological information was gathered and orchestrated in a suitable spot on the paper. The genus Trianthema comprises of 64 species. Among them, the species of T. portulacastrum has been easily known for their customary uses. Phytochemical studies showed that T. portulacastrum included trianthamine, ecdysterone, flavonoid (5,2 dihydroxy-7methoxy-6,8 dimethyl flavone), leptorumol (5,7 dihydroxy-6,8 dimethyl chromone), and other intermediary bioactive compounds such as β-sitosterol, stigmasterol, and their β-glucopyranosides, β-cyanin, 3,4-dimethoxy cinnamic acid, 5-hydroxy-2-methoxy benzaldehyde, 3-acetyl aleuritolic acid, pmethoxy benzoic acid, and p-propoxy benzoic acid. The plant extracts showed significant antioxidant, anti-inflammatory, hepatoprotective, antihyperglycemic, antimicrobial, and anticancer activities. The toxicity study conducted in animals and no noteworthy mortality found till 4 g/kg b.w. Taking into account on animal studies, T. portulacastrum have different bioactivities including antihyperglycemic, hepatoprotective, anticancer, antimicrobial and modulate different cellular signals related to control of oxidative stress and inflammation. The phytoconstituents of T. portulacastrum have a various potential to exact pharmacological benefits and possible chemotherapeutic mediator. Nevertheless, more support for such properties/dynamic constituents have been obtained from cellular and molecular studies, while clinical studies are as yet deficient. Since animal research do not constantly interpret to human conditions, additional clinical studies are also warranted to infer the full interpretation impact of T. portulacastrum for prevention of human diseases. Hence, future comprehensive clinical studies are required to warrant the therapeutic usefulness of the T. portulacastrum.