Characterization of uniaxial stiffness of extracellular matrix embedded with magnetic beads via bio-conjugation and under the influence of an external magnetic field

doi:10.1016/j.jmbbm.2013.11.012

Details of Research Outputs

Status	已发表Published
Title	Characterization of uniaxial stiffness of extracellular matrix embedded with magnetic beads via bio-conjugation and under the influence of an external magnetic field
Creator	Herath, Sahan C.B.1,2; Du, Yue 1,2; Wang, Dongan Ano 3; Liao, Kin 3; Wang, Qingguo5 ; Asada, Haruhiko Harry 2,4; Chen, Peter Chao-Yu 1,2
Date Issued	2014
Source Publication	Journal of the Mechanical Behavior of Biomedical Materials
ISSN	1751-6161
Volume	30 Pages:253-265
Abstract	In this paper, we study the deformation, and experimentally quantify the change in stiffness, of an extracellular matrix (ECM) embedded with magnetic beads that are bio-conjugated with the collagen fibers and under the influence of an external magnetic field. We develop an analytical model of the viscoelastic behavior of this modified ECM, and design and implement a stretch test to quantify (based on statistically meaningful experiment data) the resulting changes in its stiffness induced by the external magnetic field. The analytical results are in close agreement with that obtained from the experiments. We discuss the implication of these results that point to the possibility of creating desired stiffness gradients in an ECM in vitro to influence cell behavior. © 2013 Elsevier Ltd.
DOI	10.1016/j.jmbbm.2013.11.012
URL	View source
Indexed By	SCIE
Language	英语English
WOS Research Area	Engineering ; Materials Science
WOS Subject	Engineering, Biomedical ; Materials Science, Biomaterials
WOS ID	WOS:000331493900026
Citation statistics	Cited Times:6[WOS] [WOS Record] [Related Records in WOS]
Document Type	Journal article
Identifier	http://repository.uic.edu.cn/handle/39GCC9TT/3768
Collection	Research outside affiliated institution
Affiliation	1.Department of Mechanical Engineering, National University of Singapore, Singapore, Singapore 2.Biosystem and Micromechanics Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology Program, SGP, Singapore 3.Division of Bioengineering, Nanyang Technological University, Singapore, Singapore 4.Department of Mechanical Engineering, Massachusetts Institute of Technology, MA, United States 5.Department of Electrical and Computer Engineering, National University of Singapore, Singapore, Singapore
Recommended Citation GB/T 7714	Herath, Sahan C.B.,Du, Yue,Wang, Dongan Anoet al. Characterization of uniaxial stiffness of extracellular matrix embedded with magnetic beads via bio-conjugation and under the influence of an external magnetic field[J]. Journal of the Mechanical Behavior of Biomedical Materials, 2014, 30: 253-265.
APA	Herath, Sahan C.B., Du, Yue., Wang, Dongan Ano., Liao, Kin., Wang, Qingguo., .. & Chen, Peter Chao-Yu. (2014). Characterization of uniaxial stiffness of extracellular matrix embedded with magnetic beads via bio-conjugation and under the influence of an external magnetic field. Journal of the Mechanical Behavior of Biomedical Materials, 30, 253-265.
MLA	Herath, Sahan C.B.,et al."Characterization of uniaxial stiffness of extracellular matrix embedded with magnetic beads via bio-conjugation and under the influence of an external magnetic field". Journal of the Mechanical Behavior of Biomedical Materials 30(2014): 253-265.

Files in This Item:
There are no files associated with this item.

Related Services

Usage statistics

Google Scholar

If you have any objections to this item, please fill out the form below and the administrator will contact you as soon as possible.
Content:
Email：	*
Institution:
Verification Code:	Refresh

Any comments and suggestions are welcomed.
Title:	*
Content:
Email：	*
Verification Code:	Refresh