Multiple Mechanisms are Involved in Salt-Sensitive Hypertension-Induced Renal Injury and Interstitial Fibrosis

doi:10.1038/srep45952

Details of Research Outputs

Title	Multiple Mechanisms are Involved in Salt-Sensitive Hypertension-Induced Renal Injury and Interstitial Fibrosis
Creator	Wei，Shi Yao 1; Wang，Yu Xiao 1; Zhang，Qing Fang 1; Zhao，Shi Lei 1; Diao，Tian Tian 1; Li，Jian Si 1; Qi，Wen Rui 2; He，Yi Xin 1; Guo，Xin Yu 1; Zhang，Man Zhu 1; Chen，Jian Yu 1; Wang，Xiao Ting 1; Wei，Qiu Ju 1; Wang，Yu 1; Li，Bing 1
Date Issued	2017-04-06
Source Publication	Scientific Reports
Volume	7
Abstract	Salt-sensitive hypertension (SSHT) leads to kidney interstitial fibrosis. However, the potential mechanisms leading to renal fibrosis have not been well investigated. In present study, Dahl salt-sensitive (DS) rats were divided into three groups: normal salt diet (DSN), high salt diet (DSH) and high salt diet treated with hydrochlorothiazide (HCTZ) (DSH + HCTZ). A significant increase in systolic blood pressure (SBP) was observed 3 weeks after initiating the high salt diet, and marked histological alterations were observed in DSH rats. DSH rats showed obvious podocyte injury, peritubular capillary (PTC) loss, macrophage infiltration, and changes in apoptosis and cell proliferation. Moreover, Wnt/β-catenin signaling was significantly activated in DSH rats. However, HCTZ administration attenuated these changes with decreased SBP. In addition, increased renal and urinary Wnt4 expression was detected with time in DSH rats and was closely correlated with histopathological alterations. Furthermore, these alterations were also confirmed by clinical study. In conclusion, the present study provides novel insight into the mechanisms related to PTC loss, macrophage infiltration and Wnt/β-catenin signaling in SSHT-induced renal injury and fibrosis. Therefore, multi-target therapeutic strategies may be the most effective in preventing these pathological processes. Moreover, urinary Wnt4 may be a noninvasive biomarker for monitoring renal injury after hypertension.
DOI	10.1038/srep45952
URL	View source
Language	英语English
Scopus ID	2-s2.0-85017112121
Citation statistics	Cited Times:34[WOS] [WOS Record] [Related Records in WOS]
Document Type	Journal article
Identifier	http://repository.uic.edu.cn/handle/39GCC9TT/6363
Collection	Beijing Normal-Hong Kong Baptist University
Corresponding Author	Li，Bing
Affiliation	1.Department of Nephrology,Second Affiliated Hospital of Harbin,Medical University,Harbin,China 2.Financial Mathematics,Beijing Normal University-Hong Kong,Baptist University United International College,Zhuhai,China
Recommended Citation GB/T 7714	Wei，Shi Yao,Wang，Yu Xiao,Zhang，Qing Fanget al. Multiple Mechanisms are Involved in Salt-Sensitive Hypertension-Induced Renal Injury and Interstitial Fibrosis[J]. Scientific Reports, 2017, 7.
APA	Wei，Shi Yao., Wang，Yu Xiao., Zhang，Qing Fang., Zhao，Shi Lei., Diao，Tian Tian., .. & Li，Bing. (2017). Multiple Mechanisms are Involved in Salt-Sensitive Hypertension-Induced Renal Injury and Interstitial Fibrosis. Scientific Reports, 7.
MLA	Wei，Shi Yao,et al."Multiple Mechanisms are Involved in Salt-Sensitive Hypertension-Induced Renal Injury and Interstitial Fibrosis". Scientific Reports 7(2017).

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